aTyr Pharma Announces Positive Phase 1 Data for ATYR1923 Therapeutic Candidate

aTyr Pharma (Nasdaq:LIFE), a biotherapeutics company engaged in the discovery and development of innovative medicines based on novel immunological pathways, today announced positive data from its Phase 1 clinical trial of ATYR1923, an immuno-modulatory therapeutic candidate with potentially broad therapeutic application in the treatment of interstitial lung diseases.

As quoted in the press release:

The pharmacokinetics (PK) of ATYR1923 following single-dose administration were linear across the evaluated dose range. Higher ATYR1923 doses yielded sustained serum concentrations through the end of the one-month follow-up period that were above the predicted therapeutic threshold, supporting the potential for a once-monthly dosing regimen.

“We are encouraged by our Phase 1 safety and tolerability data, which support the continued clinical development of ATYR1923 for patients with inflammatory interstitial lung disease,” said Sanjay Shukla, M.D., M.S., President and CEO of aTyr. “The PK profile of ATYR1923 supports once monthly dosing, which we believe would be attractive to our potential patient population. This is an important first step in our clinical program for ATYR1923 and we will be using this data alongside our ATYR1923 translational research activities as we develop and initiate a patient trial in the fourth quarter of this year.”

Click here to read the full press release.