Dyadic International Improves Monoclonal Antibody (mAb) Productivity Utilizing C1 Gene Expression Platform to Manufacture Biologics

Dyadic International (OTCQX:DYAI) has provided an update on its monoclonal antibody (mAb) productivity yield using the C1 platform from 1.34 to 2.46 grams per day, which is an 84 percent increase.

As quoted in the press release:

 Dyadic reached 9 grams per liter of the target mAb in only 90 hours with 50 percent of the total protein produced as the target mAb. This was accompanied by a 67 percent decrease in media cost. These improvements were conducted by one of Dyadic’s contract research organizations. These results were presented by Dr. Ronen Tchelet, Dyadic’s Vice President of Research & Development, at the Global Bioprocessing and Bioanalytics Congress 2018 in Prague on May 24-25. To view Dr. Tchelet’s presentation, please visit the following link: https://www.dyadic.com/wp-content/uploads/2018/01/C1-Technology-Bioprocessing-Prague-May-24-2018.pdf.

“Dyadic was able to achieve what we believe are record results in a relatively short time by identifying low-cost chemically defined media and applying proprietary optimization and process development to demonstrate record levels of monoclonal antibody productivity,” Mr. Emalfarb said. “We are continuing our R&D efforts and working with partners to further develop our C1 gene expression platform to become the platform of choice for manufacturing protein-based biologics because of speed of development and low cost of goods. The first wave of biologics that we hope to develop are non-glycosylated Fab proteins, followed by glycoproteins, and we expect to update our stakeholders on the timing of these milestones.”

Click here to read the full press release.