Clementia Reports Positive Phase 2 Part B Data Showing Treatment with Palovarotene Significantly Reduces New Bone Growth in Patients with FOP

Clementia Pharmaceuticals (NASDAQ:CMTA), a clinical-stage biopharmaceutical company innovating new treatments for people with ultra-rare bone disorders and other diseases, today reported positive data from Part B of the company’s ongoing Phase 2 clinical trial evaluating palovarotene, an RARγ agonist, for the treatment of patients with fibrodysplasia ossificans progressiva, or FOP.

As quoted in the press release:

“We are very pleased to report these preliminary positive data from Part B of our Phase 2 trial and are encouraged by palovarotene’s potential to be the first-ever approved treatment for patients with FOP,” said Clarissa Desjardins, Ph.D., co-founder and chief executive officer of Clementia. “We recently surpassed enrollment of the first 35 patients in our Phase 3 MOVE Trial, and are on track to complete study enrollment by the end of the year. Based on this, we are also on-track to reach our first interim analysis in mid-2019, bringing us one step closer to being able to provide this important potential treatment to the many patients in need.”

“FOP is a rare, genetic bone disease that results in uncontrolled extra-skeletal bone growth for which there are no approved treatments,” said study principal investigator Frederick Kaplan, M.D., the Isaac & Rose Nassau professor of orthopaedic molecular medicine and chief of the Division of Molecular Orthopaedic Medicine in the Perelman School of Medicine at the University of Pennsylvania. “The preliminary data presented from this Phase 2 trial suggest that treatment with palovarotene may significantly reduce the development of new HO from flare-ups in patients with FOP. Palovarotene’s reported safety profile to date is also promising. I look forward to continuing to work with Clementia and participating in the ongoing Phase 3 MOVE Trial.”

Click here to read the full press release.