IntelGenx Partners with Tilray to Create Cannabis-infused Oral Strips
As the October legalization of cannabis edibles in Canada nears, marijuana firms in the country have been working to develop a host of foods and beverages — from gummies to cannabis-infused pop — for the recreational market.
Now consumers will be able to experience the effects of cannabis in a new form: oral strips.
IntelGenx (TSXV:IGX,OTCQX:IGXT), an oral drug delivery company, is working with Tilray (NASDAQ:TLRY) to create cannabis-infused films for both recreational and medical use, with plans to distribute them across Canada later this year and internationally.
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The Investing News Network (INN) spoke with IntelGenx CEO Horst Zerbe and CFO Andre Godin about the newest addition to the realm of edible marijuana products.
Conventional methods of taking drugs — like swallowing pills — create a situation where the active ingredients reach the liver where they are “metabolically destroyed” before entering the bloodstream, said Zerbe. Oral films, however, circumvent that issue.
“Oral absorption of the active (ingredient), whether that be (tetrahydrocannabinol) or (cannabidiol), leads to a direct migration of the active (ingredient) into the bloodstream,” Zerbe told INN. “The result is more drugs available for … therapeutic activities.”
He added that the company’s use of its VersaFilm technology will contain a carefully measured amount of the drug, offering precise dosing and reduced side effects to consumers, and will be packaged individually in child-proof pouches.
Zerbe said the cannabis film is intended to ensure the rapid onset of action once the drug is absorbed into the oral mucosa, the membrane that lines the inside of the mouth.
The Quebec-based pharmaceutical company inked the letter of intent with Tilray in September last year, agreeing to split the funding costs 80/20, with Tilray taking on the majority of the research and development and commercialization expenses. Though the products will be co-developed by both companies, Tilray will have exclusive distribution and marketing rights.
As a part of the deal, Tilray purchased 1.25 million common shares of IntelGenx at US$0.80 each.
The cannabis strips are set to be IntelGenx’s first commercial oral film product and will be marketed as adult-use items.
IntelGenx set out on this journey in earnest with Zerbe, the co-inventor of Listerine strips, at its helm earlier this year when it received its first shipment of cannabis extract from Tilray in May. In the months since, IntelGenx has been successful in infusing the strips with cannabis, adjusting for performance parameters like dissolve rate and residue, and is currently working on final improvements.
Before cannabis became legal in Canada, IntelGenx conducted research on the marijuana market in September 2018, the results of which encouraged the firm to further its research.
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An online survey of 1,000 Canadians aged 19 to 80 found that 78 percent of people were likely to try a cannabis-infused dissolvable film for recreational use. That number jumped to 86 percent when people were asked about the likelihood of them using a film for medical purposes.
The research also found the appeal of oral films lies in their ease of use, discreetness and lack of harmful smoke.
Godin said the company was surprised by the results. After the market research, IntelGenx was approached by several cannabis companies before choosing to partner with Tilray. Godin cited the company’s medical program as a selling point.
However, the company faced a setback in April this year when the US Food and Drug Administration (FDA) issued a complete response letter to the pharmaceutical firm’s new drug application for Rizaport, a film created for migraine treatment. The federal agency requested more information for the chemistry, manufacturing and controls sections of the application.
IntelGenx’s shares dropped to C$0.70 from C$0.90 when news of the letter broke. Its share price sat at C$0.55 as of 10:05 a.m. EDT on Wednesday (September 4), a value decrease of almost 40 percent.
In its results for Q2 of this year, IntelGenx reported revenues of C$197,000, down from the C$234,000 reported in Q2 last year. The company attributed the decrease to a loss of research and development revenue. There was also a net loss of C$2.5 million for this quarter. Cash and short-term investments, however, were at C$6.1 million as of the quarter’s end, up from C$3.7 million in 2018’s Q2.
Godin ascribed some of the pressure on the stock to the FDA’s letter, saying the market “overreacted” to the news. He added that the company is prepared to resubmit its application for the migraine film this month.
The launch of the cannabis oral strips is expected to have a positive share price impact, Godin continued.
The executive also said IntelGenx’s position as a pharmaceutical company ensures its edible products will be made under good manufacturing practices, setting it apart from other edible producers.
Zerbe mentioned that, though the first round of cannabis films to hit the market will be for adult use, further forms of the strips will be directed at medical patients.
“We see immense potential in the medical space,” said Zerbe, adding that a cannabis film can be used to address conditions including schizophrenia and Parkinson’s disease.
Apart from marijuana films, IntelGenx is expected to launch strips for migraines and erectile dysfunction between 2020 and 2021.
Don’t forget to follow us @INN_Cannabis for real-time news updates!
Securities Disclosure: I, Danielle Edwards, hold no direct investment interest in any company mentioned in this article.
Editorial Disclosure: The Investing News Network does not guarantee the accuracy or thoroughness of the information reported in the interviews it conducts. The opinions expressed in these interviews do not reflect the opinions of the Investing News Network and do not constitute investment advice. All readers are encouraged to perform their own due diligence.
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– Virtual Investor Conferences and KCSA Strategic Communications today announced the agenda for the upcoming KCSA Cannabis Industry Virtual lnvestor Conference. Individual investors, institutional investors, advisors and analysts are invited to attend. The program opens at 10:15 AM ET, with the first live webcast at 10:30 AM ET, on Tuesday, April 20 th .
REGISTER NOW AT: https://bit.ly/329Ti0Y
It is recommended that investors pre-register and run the online system check to expedite participation and receive event updates. There are no fees to log-in, attend the live presentations or ask questions.
April 20 th Agenda:
Eastern |
Full Company |
Ticker(s) |
10:30 AM |
IM Cannabis Corp. |
(NASDAQ: IMCC | CSE: IMCC) |
11:00 AM |
Aleafia Health Inc. |
(OTCQX: ALEAF | TSX: AH) |
11:30 AM |
Clever Leaves Holdings Inc. |
(NASDAQ: CLVR, CLVRW) |
12:00 PM |
(OTCQX: FFNTF | CSE: FFNT) |
|
12:30 PM |
Fire & Flower Holdings Corp. |
(OTCQX: FFLWF | TSX: FAF) |
1:00 PM |
The Valens Company Inc. |
(OTCQX: VLNCF | TSX: VLNS) |
1:30 PM |
Slang Worldwide Inc. |
(OTCQB: SLGWF | CSE: SLNG) |
2:00 PM |
ManifestSeven Holdings Corp. |
(Pink: MNFSF | CSE: MSVN) |
2:30 PM |
Stem Holdings, Inc. |
(OTCQX: STMH | CSE: STEM) |
3:00 PM |
Australis Capital Inc. |
(OTCQB: AUSAF | CSE: AUSA) |
3:30 PM |
Experion Holdings Ltd. |
(OTCQB: EXPFF | TSX-V: EXP) |
4:00 PM |
Sugarbud Craft Growers Corp. |
(OTCQB: SBUDF | TSX-V: SUGR) |
4:30 PM |
Fiore Cannabis Ltd. |
(OTCQX: FIORF | CSE: FIOR) |
To facilitate investor relations scheduling, for more information about the program and to view a complete calendar of Virtual Investor Conferences, please visit
www.virtualinvestorconferences.com .
About Virtual Investor Conferences SM
Virtual Investor Conferences (VIC) is the leading proprietary investor conference series that provides an interactive forum for publicly-traded companies to meet and present directly with investors.
A real-time solution for investor engagement, Virtual Investor Conferences is part of OTC Market Group’s suite of investor relations services specifically designed for more efficient Investor Access. Replicating the look and feel of on-site investor conferences, Virtual Investor Conferences combine leading-edge conferencing and investor communications capabilities with a comprehensive global investor audience network.
About KCSA Strategic Communications
KCSA Strategic Communications ( www.kcsa.com ) is a fully-integrated communications agency specializing in public relations, investor relations, social media and marketing with expertise in financial and professional services, technology, healthcare, cannabis, media and energy companies. Since 1969, the firm has demonstrated strategic thinking and program execution that drives results for its clients in the ever-changing communications and digital landscape. The firm’s clients are its best references.
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4Front Ventures
Launching Digital Sales Platform
Global Wellness Strategies Inc. (CSE: LOAN) (FSE: O3X4) (OTCQB: PNNRD) (formerly Redfund Capital Corp.) (“Global” or the “Company”) announces KaleidoMyco agreement with digital marketing firm The Wolf of Marketing to launch digital sales platform.
KaleidoMyco is about the creation of a strong bond with online consumers and bucking the trend of having to go to stores during the new wave of Covid 19. Building a robust digital sales platform to immediately roll out new hemp extract infused functional mushroom SKUs is the first stage of building a trailblazer in myco wellness products.
The Wolf of Marketing was founded by Adam Stamatis, a full-service marketing agency that helps companies build an online presence and drive growth and sales. Within 20+ years, The Wolf of Marketing has become the industry’s leader for building user-friendly custom websites with time-tested digital strategies that focus on customer acquisition and retention. Adam Stamatis and The Wolf of Marketing team are excited to partner with KaleidoMyco and help identify gaps, create a better web platform, and build a customized strategy that aligns with our unique business needs.
“Creating the #1 global brand of hemp extract infused myco products is foremost to KaleidoMyco. This signing represents a major collaboration for KaleidoMyco, working together closely with Adam and his team to help build the revenues of the company. The Wolf of Marketing has the experience we’ve been looking for because they worked with top-hemp companies and increased their ROI.” Stated Meris Kott, CEO, Global Wellness Strategies Inc.
About KaleidoMyco
KaleidoMyco is the world’s first company combining hemp extract, adaptogens and myco based ingredients to produce world-class, data-driven, science-based wellness products. It is dedicated to driving ground-breaking innovations in the production and delivery of myco derived formulations. KaleidoMyco has a team of experts who are actively working to lay the foundation in the psilocybin space as more developments in regulation become available.
About Global Wellness Strategies
Global Wellness Strategies is a prospect generator that provides high growth companies with financial, operational, and management assistance in the fast-growing market for wellness consumer products. The focus of the Company is on global wellness, hemp and CBD, healthcare-related target companies.
For further information please visit out website : www.globalwellnessstrategies.com
Or Contact Meris Kott CEO 604.484.0355 or email to info@globalwellnessstrategies.com
Further information about the Company is available on www.SEDAR.com under the Company’s profile.
Neither the Canadian Securities Exchange nor its Regulation Services Provider (as that term is defined in the policies of the Canadian Securities Exchange) accepts responsibility for the adequacy or accuracy of this release. Certain statements contained in this release may constitute “forward-looking statements” or “forward-looking information” (collectively “forward-looking information”) as those terms are used in the Private Securities Litigation Reform Act of 1995 and similar Canadian laws. These statements relate to future events or future performance. The use of any of the words “could”, “intend”, “expect”, “believe”, “will”, “projected”, “estimated”, “anticipates” and similar expressions and statements relating to matters that are not historical facts are intended to identify forward-looking information and are based on the Company’s current belief or assumptions as to the outcome and timing of such future events. Actual future results may differ materially. In particular, this release contains forward-looking information relating to the business of the Company, its financing and certain corporate changes. The forward-looking information contained in this release is made as of the date hereof and the Company is not obligated to update or revise any forward-looking information, whether as a result of new information, future events or otherwise, except as required by applicable securities laws. Because of the risks, uncertainties and assumptions contained herein, investors should not place undue reliance on forward-looking information. The foregoing statements expressly qualify any forward-looking information contained herein.
To view the source version of this press release, please visit https://www.newsfilecorp.com/release/80391
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Redfund Capital
An Emerging Markets Sponsored Commentary
Health and wellness, beverage and natural products company BevCanna Enterprises Inc. (CSE:BEV, Q:BVNNF, FSE:7BC) recently announced that following the appointment of former Pepsi Co. executive, Melise Panetta to President of the organization. it has further bolstered its leadership team with veteran consumer packaged goods (“CPG”) expertise, which is anticipated to deepen and expand BevCanna’s existing sales and distribution network, and accelerate growth.
To that end, the announcement that it has added two veteran CPG (Consumer Packaged Goods) senior sales leaders to the organization is noteworthy. According to the release , Raffael Kapusty will join the company as Vice-President of Sales and Insights and Bill Niarchos will hold the role of Vice-President of Sales and Sales Operations.
Both executives have impressive resumes that dovetail nicely into BevCanna’s strategic growth and expansion trajectory. The release explains that the pair will work collaboratively to accelerate BevCanna’s transformation into a diversified beverage and natural products company with a multi-channel sales and distribution network.
Priorities will include further bolstering BevCanna’s white-label clientele and expanding its international CPG distribution network of U.S. and Canadian big box retailers.
To that end, Raffael Kapusty is an accomplished CPG industry leader with more than 25 years of experience in both the Canadian and U.S. retail spaces. Some of the big names she has worked with and for include ACNielsen Canada and over 100 leading Canadian & global CPG manufacturers. Notably, she has also held senior category and key account management roles at Kruger, SC Johnson and Unilever Canada.
Those relationships and expertise will be joined by Niarchos’ formidable CV which includes Director of Sales with Bayer Consumer Health and managing the strategic direction and growth of Loblaw & SDM. The veteran executive has held a number of progressive roles including Colgate Palmolive for more than 14 years and helped manage trade channels in various capacities, including as National Account Manager at Walmart and Costco.
The caliber of personnel and deep expertise in consumer-packaged goods is expected to add immense value that the Company believes will help make BevCanna a big name in its own right in the future.
About The Emerging Markets Report:
The Emerging Markets Report is owned and operated by Emerging Markets Consulting (EMC), a syndicate of investor relations consultants representing years of experience. Our network consists of stockbrokers, investment bankers, fund managers, and institutions that actively seek opportunities in the micro and small-cap equity markets.
For more informative reports such as this, please sign up at http://www.emergingmarketsllc.com/newsletter.php
Must Read OTC Markets/SEC policy on stock promotion and investor protection
- https://www.otcmarkets.com/learn/policy-on-stock-promotion
- https://www.otcmarkets.com/learn/investor-protection
- https://www.sec.gov/news/press-release/2017-79
- https://www.sec.gov/oiea/investor-alerts-bulletins/ia_promotions.html
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We may purchase Securities of the Profiled Company prior to their securities becoming publicly traded, which we may later sell publicly before, during or after our dissemination of the Information, and make profits therefrom. EMC does not verify or endorse any medical claims for any of its client companies.
EMC has been paid $350,000 by BevCanna Enterprises, Inc. for various marketing services including this report. EMC does not independently verify any of the content linked-to from this editorial. http://emergingmarketsllc.com/disclaimer.php
Emerging Markets Consulting, LLC
Florida Office
390 North Orange Ave Suite 2300,
Orlando, FL 32801
E-mail: jamespainter@emergingmarketsllc.com
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BevCanna
Lexaria’s DehydraTECH Technology Utilized in Amari’s “Everyday Calm,” Named a Top CBD Product Pick by New Hope Network
-
– DehydraTECH TM Powers Amari’s Award-Winning Products
Kelowna, British Columbia TheNewswire – April 14, 2021 Lexaria Bioscience Corp. (Nasdaq:LEXX) (Nasdaq:LEXXW) (CSE:LXX) (CNSX:LXX.CN) (the “Company” or “Lexaria”), a global innovator in drug delivery platforms, announced that its corporate client Amari Corp.’s “Everyday Calm” CBD product was named a Top CBD Product Pick by New Hope Network host of the industry-leading Natural Products Expo conference events. Hundreds of CBD products competed to be among “New Hope Network editors’ Top Picks for 2020”.
Eric Gricus, CEO and Founder of Amari, commented, “ Amari went through an extensive selection process for our CBD technology supplier. Lexaria exceeded our expectations for product quality, service and pricing. We are thrilled to have the Lexaria team working with Amari to help us develop products our customers love and to win industry accolades.”
Lexaria’s DehydraTECH TM technology delivers CBD more quickly and effectively, as evidenced in repeated studies, to enhance consumer satisfaction and strengthen brand loyalty.
“Lexaria is delighted to have been able to work with Amari and their award-winning products,” said Chris Bunka, CEO of Lexaria. “DehydraTECH is gaining more widespread consumer support and we expect to see products utilizing DehydraTECH technology in more and more stores across America as the year unfolds.”
About Lexaria Bioscience Corp.
Lexaria Bioscience Corp.’s proprietary drug delivery technology, DehydraTECH™, improves the way active pharmaceutical ingredients (APIs) enter the bloodstream by promoting healthier oral ingestion methods and increasing the effectiveness of fat-soluble active molecules, thereby lowering overall dosing. The Company’s technology can be applied to many different ingestible product formats, including foods, beverages, oral suspensions, tablets, and capsules. DehydraTECH has repeatedly demonstrated since 2016 with cannabinoids and nicotine the ability to increase bio-absorption by up to 5-10x, reduce time of onset from 1 – 2 hours to minutes, and mask unwanted tastes; and is planned to be further evaluated for orally administered bioactive molecules, including anti-virals, cannabinoids, vitamins, non-steroidal anti-inflammatory drugs (NSAIDs), and nicotine. Lexaria has licensed DehydraTECH to multiple companies including a world-leading tobacco producer for the development of smokeless, oral-based nicotine products and for use in industries that produce cannabinoid beverages, edibles, and oral products. Lexaria operates a licensed in-house research laboratory and holds a robust intellectual property portfolio with 18 patents granted and approximately 60 patents pending worldwide. For more information, please visit www.lexariabioscience.com .
About Amari
Founded in 2019, Amari was launched by outdoor enthusiast, Eric Gricus, for people like him. People who love to be active, but who may have noticed as they get older that the spirit is willing, but the body often has aches and pains and soreness after a day of hiking, skiing or rafting. To create the product, Eric leveraged his more than 10 years’ experience working with early-stage CPG companies and commercializing research from a university setting. Amari formulas blend science and technology to provide authentic, plant-based remedies that deliver tangible benefits to support a lifestyle of wellness and vitality, while being rooted in transparency and extensive quality controls.
CAUTION REGARDING FORWARD-LOOKING STATEMENTS
This press release includes forward-looking statements. Statements as such term is defined under applicable securities laws. These statements may be identified by words such as “anticipate,” “if,” “believe,” “plan,” “estimate,” “expect,” “intend,” “may,” “could,” “should,” “will,” and other similar expressions. Such forward-looking statements in this press release include, but are not limited to, statements by the company relating the Company’s ability to carry out research initiatives, receive regulatory approvals or grants or experience positive effects or results from any research or study. Such forward-looking statements are estimates reflecting the Company’s best judgment based upon current information and involve a number of risks and uncertainties, and there can be no assurance that the Company will actually achieve the plans, intentions, or expectations disclosed in these forward-looking statements. As such, you should not place undue reliance on these forward-looking statements. Factors which could cause actual results to differ materially from those estimated by the Company include, but are not limited to, government regulation and regulatory approvals, managing and maintaining growth, the effect of adverse publicity, litigation, competition, scientific discovery, the patent application and approval process, potential adverse effects arising from the testing or use of products utilizing the DehydraTECH technology, the Company’s ability to maintain existing collaborations and realize the benefits thereof, delays or cancellations of planned R&D that could occur related to pandemics or for other reasons, and other factors which may be identified from time to time in the Company’s public announcements and periodic filings with the US Securities and Exchange Commission on EDGAR. There is no assurance that any of Lexaria’s postulated uses, benefits, or advantages for the patented and patent-pending technology will in fact be realized in any manner or in any part. No statement herein has been evaluated by the Food and Drug Administration (FDA). Lexaria-associated products are not intended to diagnose, treat, cure or prevent any disease. Any forward-looking statements contained in this release speak only as of the date hereof, and the Company expressly disclaims any obligation to update any forward-looking statements contained herein, whether as a result of any new information, future events, changed circumstances or otherwise, except as otherwise required by law.
The CSE has not reviewed and does not accept responsibility for the adequacy or accuracy of this release.
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Lexaria Bioscience
Green Cush and Sour Kush to launch under the ‘Vert’ brand with more to follow in 2021
Canopy Growth Corporation (“Canopy Growth” or the “Company”) (TSX: WEED) (NASDAQ: CGC), a world-leading diversified cannabis, hemp, and vaporization device company, is announcing the launch of Vert, the Company’s first Quebec -exclusive brand. The first two strains to launch under the Vert brand are ‘Green Cush’ and ‘Sour Kush’, which will be sold via the Société québécoise du cannabis (SQDC) in dried flower and pre-roll joint formats. Vert Green Cush is a sativa-dominant strain and Sour Kush is an indica-dominant strain.
“At Canopy Growth, we understand the importance of providing the Quebec market with a regionally-exclusive brand,” said Kelly Olsen , Vice President of Global Flower Business at Canopy Growth. “Vert cannabis is grown by an experienced community of Quebecois cultivators. We’re excited to bring a new offering of local cannabis flower to SQDC shelves.”
Vert Green Cush and Sour Kush are cultivated at Vert Mirabel, a fully licensed, hi-tech greenhouse located in Mirabel, Quebec that is jointly owned by Canopy Growth and partner Les Serres Stéphane Bertrand Inc., a multi-generational greenhouse operated in the province. Vert Mirabel is one of Canopy Growth’s primary cannabis cultivation facilities and plays a role in providing locally-grown cannabis for the Quebec market – cementing the company’s production footprint in the province. The facility employs more than 200 people in the Mirabel region in key roles ranging from growers to production managers.
“The operation of our Vert Mirabel facility is guided by a team of incredibly passionate growers that are dedicated to bringing locally grown cannabis to Quebec ,” said Sylvain Miron , Director, Vert Mirabel. “This product is truly a fusion of Canopy’s cannabis expertise with the Vert Mirabel team’s multi-generational knowledge in greenhouse operations.”
For more information on how to shop COVID-19 compliant ways online and in-store visit www.sqdc.ca .
Here’s to Future Growth.
About Canopy Growth Corporation
Canopy Growth (TSX: WEED ,NASDAQ: CGC) is a world-leading diversified cannabis and cannabinoid-based consumer product company, driven by a passion to improve lives, end prohibition, and strengthen communities by unleashing the full potential of cannabis. Leveraging consumer insights and innovation, we offer product varieties in high quality dried flower, oil, softgel capsule, infused beverage, edible, and topical formats, as well as vaporizer devices by Canopy Growth and industry-leader Storz & Bickel. Our global medical brand, Spectrum Therapeutics, sells a range of full-spectrum products using its colour-coded classification system and is a market leader in both Canada and Germany . Through our award-winning Tweed and Tokyo Smoke banners, we reach our adult-use consumers and have built a loyal following by focusing on top quality products and meaningful customer relationships. Canopy Growth has entered into the health and wellness consumer space in key markets including Canada , the United States , and Europe through BioSteel sports nutrition, and This Works skin and sleep solutions; and has introduced additional federally-permissible CBD products to the United States through our First & Free and Martha Stewart CBD brands. Canopy Growth has an established partnership with Fortune 500 alcohol leader Constellation Brands. For more information visit www.canopygrowth.com .
Notice Regarding Forward Looking Statements
This press release contains “forward-looking statements” and “forward-looking information” within the meaning of applicable U.S. and Canadian securities laws (collectively, “forward-looking statements”), which involve certain known and unknown risks and uncertainties. Forward-looking statements predict or describe our future operations, business plans, business and investment strategies and the performance of our investments. These forward-looking statements are generally identified by their use of such terms and phrases as “intend,” “goal,” “strategy,” “estimate,” “expect,” “project,” “projections,” “forecasts,” “plans,” “seeks,” “anticipates,” “potential,” “proposed,” “will,” “should,” “could,” “would,” “may,” “likely,” “designed to,” “foreseeable future,” “believe,” “scheduled” and other similar expressions. You are cautioned not to place undue reliance on these forward-looking statements, which speak only as of the date the statement was made. Forward–looking statements are necessarily based upon a number of estimates and assumptions that, while considered reasonable by management, are inherently subject to significant business, economic and competitive risks, financial results, results, performance or achievements expressed or implied by those forward–looking statements and the forward-looking statements are not guarantees of future performance. Accordingly, there are or will be important factors that could cause actual outcomes or results to differ materially from those indicated in these statements. A discussion of some of the material factors applicable to Canopy Growth can be found under the section entitled “Risk Factors” in Canopy Growth’s Annual Report on Form 10-K for the year ended March 31, 2020, filed with the Securities and Exchange Commission and with applicable Canadian securities regulators, as such factors may be further updated from time to time in its periodic filings with the Securities and Exchange Commission and with applicable Canadian securities regulators, which can be accessed at www.sec.gov/edgar and www.sedar.com , respectively. These factors should not be construed as exhaustive and should be read in conjunction with the other cautionary statements that are included in this press release and in the filings. Any forward–looking statement included in this press release is made as of the date of this press release and, except as required by law, Canopy Growth disclaims any obligation to update or revise any forward-looking statement. Readers are cautioned not to put undue reliance on any forward-looking statement. Forward-looking statements contained in this press release are expressly qualified by this cautionary statement.
SOURCE Canopy Growth Corporation
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