Genetics

Mesoblast (Nasdaq:MESO) (ASX:MSB) today provided an update on the Phase 3 and Phase 2b clinical trials of the Company’s proprietary allogeneic mesenchymal precursor cell (MPC) product candidate MPC-150-IM in patients with moderate-to-severe and end-stage advanced chronic heart failure (CHF), respectively. These indications represent major unmet medical needs due to the high rates of morbidity and …

Mesoblast (Nasdaq:MESO) (ASX:MSB) today provided an update on the Phase 3 and Phase 2b clinical trials of the Company’s proprietary allogeneic mesenchymal precursor cell (MPC) product candidate MPC-150-IM in patients with moderate-to-severe and end-stage advanced chronic heart failure (CHF), respectively. These indications represent major unmet medical needs due to the high rates of morbidity and mortality despite existing therapies.

As quoted in the press release:

In the United States alone, there are more than 1.3 million patients with New York Heart Association (NYHA) Class III CHF, 250,000 patients with NYHA Class IV CHF, and 50,000 patients with end-stage CHF, representing a potential multi-billion dollar market opportunity for Mesoblast.

Positive clinical signals have been previously published in Phase 2 trials of Mesoblast’s MPC therapy in advanced and end-stage heart failure1,2, supporting a common underlying mechanism of action (MOA). The MOA by which MPC-150-IM is thought to exert its effects in these patient populations, based on preclinical evidence, is through reduction of damaging inflammation, maturation of the vasculature, and cardiac repair.

Click here to read the full press release.

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