Clementia Announces Completion of Enrollment in Phase 3 MOVE Trial for FOP

Clementia Pharmaceuticals (NASDAQ:CMTA), a clinical-stage company innovating treatments for individuals with ultra-rare bone disorders and other diseases, today announced the early completion of patient enrollment in the MOVE Trial, Clementia’s registrational Phase 3 clinical study evaluating the safety and efficacy of palovarotene for the treatment of patients with fibrodysplasia ossificans progressiva (FOP). A total of 99 patients were enrolled in the MOVE Trial at 15 sites in 11 countries worldwide.

As quoted in the press release:

Based on the early completion of enrollment, Clementia will conduct two interim data analyses in 2019: the first when the first 35 enrolled patients have had their 12-month whole body CT (WBCT) scans, expected in the second quarter of 2019, and the second when all enrolled patients have had their 12-month WBCT scans, expected in the second half of 2019. Final 24-month results from this study are expected in the fourth quarter of 2020.

“The enthusiastic response to the MOVE Trial amongst the FOP medical and patient communities has resulted in the completion of enrollment in the MOVE Trial four months ahead of schedule,” said Clarissa Desjardins, Ph.D., president and chief executive officer of Clementia. “I’d like to thank the patient participants and their families, as well as our study investigators and their clinical teams, whose dedication has helped advance palovarotene for the potential future treatment of FOP patients who have no approved treatment options today.”

Click here to read the full press release.