GeoVax Gets Financial Award For HIV Vaccine

- April 3rd, 2017

GeoVax Labs received a grant for $658,159 from the National Institute of Allergy and Infectious Disease in support of its HIV vaccine development program.

GeoVax Labs (OTCQB:GOVX) received a grant for $658,159 from the National Institute of Allergy and Infectious Disease (NIAID) in support of its HIV vaccine development program.
As quoted in the press release:

The grant, entitled “Enhancing Protective Antibody Responses for a DNA/MVA HIV Vaccine”, supports preclinical studies in non-human primates (NHP) evaluating the immunogenicity and protective efficacy of the GeoVax Clade B HIV preventive vaccine (GOVX-B11) with or without a bivalent (two component) protein boost. Clade B is the subtype of HIV most prevalent in the developed world — primarily the Americas, Western Europe, Australia and Japan.
GOVX-B11 is a DNA/MVA vaccine that expresses non-infectious virus-like particles (VLPs). Clinical trials for GOVX-B11 are being conducted by the HIV Vaccine Trials Network (HVTN) with funding from NIAID. The HVTN has tested various doses and combinations of the DNA and MVA (MVA62B) vaccines in 500 people, and is currently testing a late protein boost in individuals who participated in the HVTN 205 Phase 2a trial of GOVX-B11. In this trial (HVTN 114), these “late boosts” consist of the GeoVax MVA62B vaccine with or without a gp120 protein vaccine. The gp120 protein is the same protein used to boost immune responses in the partially protective RV144 trial in Thailand, and is being used to assess the effect of late boosts of GOVX-B11.
While HVTN 114 is ongoing, newer proteins are being manufactured to be used as the bivalent boost in future clinical trials of GOVX-B11. The preclinical studies funded by this SBIR grant are testing these newer proteins in nonhuman primates (NHP) for the potential to increase the protective potential of GOVX-B11.
Harriet L. Robinson, PhD, Director of GeoVax’s HIV vaccine program, commented, “In the first year of our SBIR program, the bivalent boost has shown excellent ability to enhance antibody responses to the V1V2 region of the HIV envelope protein (Env). We are pleased with this result because antibody to V1V2 correlated with protection in the partially successful RV144 trial in Thailand. The second year of the SBIR will allow us to test the ability of the enhanced V1V2 antibody to increase the protective level of our vaccine in NHP. Meanwhile, the cGMP products for evaluating the bivalent protein boost in humans are falling into place.”
About GeoVax
GeoVax Labs, Inc. is a clinical-stage biotechnology company developing human vaccines against infectious diseases using its Modified Vaccinia Ankara-Virus Like Particle (MVA-VLP) vaccine platform. The Company’s development programs are focused on preventive vaccines against HIV, Zika Virus, hemorrhagic fever viruses (Ebola, Sudan, Marburg, and Lassa), and malaria, as well as therapeutic vaccines for chronic Hepatitis B infections and cancers. GeoVax’s vaccine platform supports in vivo production of non-infectious VLPs from the cells of the very person receiving the vaccine, mimicking a natural infection, stimulating both the humoral and cellular arms of the immune system to recognize, prevent, and control the target infection. For more information, visit www.geovax.com.

Click here to read the full press release.

Get the latest Biotech Investing stock information

Get the latest information about companies associated with Biotech Investing Delivered directly to your inbox.

Biotech Investing

Select None
Select All

Leave a Reply