CTD Holdings Finalizes Cooperative Agreement for Alzheimer’s Disease Research Program

CTD Holdings (OTCQB: CTDH), a clinical stage biotechnology company that develops cyclodextrin-based products for the treatment of disease with unmet medical need, announced today that the company has finalized a cooperative research agreement with Kerwin Research Center, LLC to explore the use of cyclodextrins in the treatment of Alzheimer’s disease.

As quoted in the press release:

“Since 2009, CTD has provided our proprietary hydroxypropyl beta cyclodextrin, Trappsol® Cyclo™, on a compassionate basis to patients suffering from Niemann-Pick Disease Type C (NPC), a disease that causes cholesterol accumulation in every cell in the body, and today we support two clinical trials using Trappsol® Cyclo™ for that same indication,” said N. Scott Fine, Company Chairman and CEO. “With this cooperative research program, we are proud to continue to innovate by exploring the use of Trappsol® Cyclo™ in the treatment of Alzheimer’s disease.”

Cholesterol has been linked to the formation of amyloid beta plaques, one of the hallmarks of Alzheimer’s disease. Hydroxypropyl beta cyclodextrins have been shown to clear cholesterol from cells in animal models, to stabilize cholesterol metabolism, and to reduce the formation of amyloid beta plaques. Early safety data from CTD’s two clinical trials using Trappsol® Cyclo™ intravenously for NPC (NCT02939547 and NCT02912793) showed a favorable benefit:safety profile in NPC patients, per the Company’s recent announcement.

Click here to read the full press release.