Alpine Immune Sciences Shares New Preclinical Data

Alpine Immune Sciences (NASDAQ:ALPN) announced it released the results of a preclinical study of immuno-oncology molecules derived from the company’s variant immunoglobulin (Ig) domain (vIgD) platform.

As quoted in the press release:

Alpine scientists fused these novel molecules with trastuzumab with the goal of activating T cells against HER2-positive tumors in the tumor microenvironment. Results showed these trastuzumab-ICOSL “V-mAbs” promoted T cell proliferation and cytokine secretion and enhanced killing of tumor cells. The data were presented in a poster session, titled “Treatment: Novel Targets and Targeted Agents (abstract # P1-09-10),” during the 40th Annual San Antonio Breast Cancer Symposium (SABCS).

“These preclinical data clearly indicate that the V-mAb format for our unique vIgD platform can yield novel HER2-targeted, T cell-activating immunotherapies,” said Stanford Peng, M.D., Ph.D., Executive Vice President of Research and Development and Chief Medical Officer of Alpine. “With these findings, we are encouraged that the V-mAb format more broadly will be able to enable target- or tumor-specific immune modulation by our vIgDs for this and many other therapeutic applications.”

Click here to read the full press release.

Get the Latest Biotech Investing Stock Information

Get the latest information about companies associated with Biotech Investing delivered directly to your inbox.


By selecting company or companies above, you are giving consent to receive email from those companies. And remember you can unsubscribe at any time.

Biotech Stocks in 2018

Find out how the market will look this year


Leave a Reply