Concert Pharmaceuticals Completes Enrollment of 12 mg Cohort in Phase 2a Trial

Concert Pharmaceuticals (NASDAQ:CNCE) today announced that it has completed patient enrollment of the final cohort evaluating 12 mg twice daily of CTP-543 in its Phase 2a trial for the treatment of moderate-to-severe alopecia areata.

As quoted in the press release:

“It is important early on in our development program to identify the safest and most effective doses of CTP-543 for patients with a chronic autoimmune disease like alopecia areata. The evaluation of the twice daily 12 mg dose provides a comprehensive exploration of the relevant dose range for CTP-543 and positions us well for later stage development of the compound,” stated James V. Cassella, Ph.D., Chief Development Officer of Concert Pharmaceuticals.

The Phase 2a trial is a double-blind, randomized, placebo-controlled, sequential dose trial to evaluate the safety and efficacy of CTP-543 in adult patients with moderate-to-severe alopecia areata. Patients were sequentially randomized to receive one of three doses of CTP-543 (4 mg, 8 mg, or 12 mg) or placebo twice daily. The primary outcome measure utilizes the severity of alopecia tool (SALT) after 24 weeks of dosing. Additional information about the trial is available on www.clinicaltrials.gov.

Click here to read the full press release.