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Incyte Announces First Patient Treated in Phase 3 Clinical Trial
Incyte (Nasdaq:INCY) today announced that the first patient has been treated in GRAVITAS-309, a pivotal Phase 3 trial for the first-line treatment of patients with chronic graft-versus-host disease (GVHD). As quoted in the press release: “Given the severity of chronic GVHD, we are pleased to announce the initiation of treatment for the first patient in …
Incyte (Nasdaq:INCY) today announced that the first patient has been treated in GRAVITAS-309, a pivotal Phase 3 trial for the first-line treatment of patients with chronic graft-versus-host disease (GVHD).
As quoted in the press release:
“Given the severity of chronic GVHD, we are pleased to announce the initiation of treatment for the first patient in the GRAVITAS-309 trial, as it represents a critical next step in our comprehensive development program aiming to bring important treatment options to market that address the significant unmet needs of GVHD patients across the spectrum of the disease,” said Steven Stein, M.D., Chief Medical Officer, Incyte.
GVHD is a condition that can occur after an allogeneic stem cell transplant (the transfer of stem cells from a donor), where the donated cells initiate an immune response and attack the transplant recipients organs, leading to significant morbidity and mortality. There are two forms of GVHD, acute and chronic, which can affect multiple organ systems including the skin, gastrointestinal (digestive) tract and liver.
It is estimated that there are approximately 15,000 new cases of GVHD diagnosed each year in the U.S., Europe and Japan, where approximately 12,000 new cases are acute GVHD and 3,000 de novo cases are chronic GVHD.1,2 The prevalence of chronic GVHD in the U.S., Europe and Japan is estimated to be approximately 25,000 patients.
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