Karyopharm Reports Updated Phase 2b SADAL Data

Karyopharm Therapeutics (NASDAQ:KPTI) announced an updated clinical data from the ongoing Phase 2b study on their lead candidate selinexor with patients with relapsed or refractory diffuse large B-cell lymphoma.
As quoted in the press release:

In the SADAL study, selinexor has achieved a 33.3% overall response rate (ORR) in patients with relapsed or refractory DLBCL after at least two prior multi-agent therapies and who are ineligible for transplantation.  The observed responses continue to be durable, with a median duration of response (DOR) of greater than 7 months, including prolonged complete responses (CRs).

Updated Phase 2b SADAL Data in Relapsed or Refractory DLBCL

In the oral presentation, titled “Single Agent Oral Selinexor Exhibits Durable Responses in Relapsed/Refractory Diffuse Large B-Cell Lymphoma (DLBCL) of Both GCB and Non-GCB Subtypes: The Phase 2b SADAL Study,” Marie Maerevoet, MD, Institute Jules Bordet in Belgium, will present the updated Phase 2b SADAL data.  Per the SADAL study protocol, the updated efficacy data were restricted to the interim analysis cohort (n=63), which were previously reported at AACR 2017, and the updated safety results include updated data on all patients that received at least one dose of selinexor as of the data cutoff date.

Dr. Maerevoet commented, “We are highly encouraged by the impressive response rates that continue to be observed with single-agent oral selinexor in these heavily pretreated patients with DLBCL who have received two or more prior therapies and are not eligible for transplantation, and for whom no standard therapy exists.  Along with being clinically active and durable, including prolonged complete responses, the 60mg dose continues to be well tolerated with a low incidence of Grade 3 or greater adverse events, which were manageable with dose modifications and standard supportive care.”

Click here to read the full press release.