Fortress Biotech Announces Publication of Phase 1 Data on CNDO-109-Activated Allogeneic Natural Killer Cells in Acute Myeloid Leukemia in Biology of Blood and Marrow Transplantation

Fortress Biotech (NASDAQ:FBIO) has announced that data from a Phase 1 clinical trial evaluating its CNDO-109 activated allogenic natural kill cells in acute myeloid leukemia patients has been published in the journal Biology of Blood and Marrow Transplantation.

As quoted in the press release:

Todd A. Fehniger, M.D., Ph.D., Associate Professor of Medicine, Oncology Division at Washington University School of Medicine, and lead investigator on the Phase 1 trial, said, “This is an important early phase, dose-escalation trial that clearly identified the safety and feasibility of the innovative approach to prime donor NK cells with tumor cell lysates prior to adoptive transfer. The very durable responses that were achieved in several of the AML patients consolidated with CNDO-109-NK are exciting, and warrant further study in a larger number of patients.”

The multi-center, non-randomized, open-label, dose-escalation Phase 1 trial evaluated the maximum tolerated dose of CNDO-109-activated NK cells in 12 adult AML patients in their first complete remission who were at a high risk of relapsing. Evaluation of the safety profile, the duration of relapse-free survival and overall survival were secondary objectives.

CNDO-109-activated NK cells were prepared from a single leukapheresis product of peripheral blood mononuclear cells from a healthy, HLA-haploidentical first or second-degree relative. The NK (CD56+) cells were purified and incubated ex vivo with CNDO-109 lysate. Cytokines were not used in the incubation process.

Click here to read the full press release.