Thermo Fisher Scientific Reports Fourth Quarter and Full Year 2024 Results

Thermo Fisher Scientific Inc. (NYSE: TMO), the world leader in serving science, today reported its financial results for the fourth quarter and full year ended December 31, 2024.

Fourth Quarter and Full Year 2024 Highlights

  • Fourth quarter revenue grew 5% to $11.40 billion.
  • Fourth quarter GAAP diluted earnings per share (EPS) grew 14% to $4.78.
  • Fourth quarter adjusted EPS grew 8% to $6.10.
  • Full year revenue was $42.88 billion, flat versus prior year.
  • Full year GAAP diluted earnings per share (EPS) grew 7% to $16.53.
  • Full year adjusted EPS grew 1% to $21.86.
  • Further strengthened our industry leadership throughout the year by advancing our trusted partner status with customers, gaining market share and delivering differentiated financial performance, including strong revenue and earnings growth in the fourth quarter.
  • Continued to strengthen our industry-leading commercial engine and deepen our trusted partner status with customers to accelerate their innovation and enhance their productivity. Highlights included the introduction of Acceleratorâ„¢ Drug Development in the fourth quarter. This integrated offering combines our unique expertise and capabilities in clinical research services and contract manufacturing to streamline the drug development process, enabling increased speed, simplicity and scalability, helping our customers to improve the return on their R&D investments. During the year, we also continued to expand collaborations with our customers, highlighted by the recently announced partnership with the University of Arkansas for Medical Sciences (UAMS) to establish the Thermo Fisher Scientific Center of Excellence for Proteomics at UAMS and, earlier in the year, the partnership with the National Cancer Institute on the myeloMATCH precision medicine umbrella trial.
  • Continued to successfully execute our capital deployment strategy in 2024. During the year we completed the acquisition of Olink , a leading provider of advanced solutions for proteomics research. Additionally in the year, we returned $4.6 billion of capital to shareholders through stock buybacks and dividends.

"We finished 2024 with excellent financial performance, delivering strong growth on the top and bottom line in the fourth quarter," said Marc N. Casper, chairman, president and chief executive officer of Thermo Fisher Scientific. "We drove meaningful share gain and enabled the success of our customers, by leveraging our proven growth strategy and PPI Business System, capping off another year of differentiated performance."

Casper added, "We are in a great position to deliver excellent performance in 2025 as we continue to create value for all of our stakeholders and build an even brighter future for our company."

Fourth Quarter 2024

Revenue for the quarter grew 5% to $11.40 billion in 2024 versus $10.89 billion in the same quarter of 2023. Organic revenue growth was 4% and Core organic revenue growth was 5%.

GAAP Earnings Results

GAAP diluted EPS in the fourth quarter of 2024 was $4.78, versus $4.20 in the same quarter last year. GAAP operating income for the fourth quarter of 2024 was $2.02 billion, compared with $1.85 billion in the year-ago quarter. GAAP operating margin was 17.7%, compared with 17.0% in the fourth quarter of 2023.

Non-GAAP Earnings Results

Adjusted EPS in the fourth quarter of 2024 was $6.10, versus $5.67 in the fourth quarter of 2023. Adjusted operating income for the fourth quarter of 2024 was $2.72 billion, compared with $2.55 billion in the year-ago quarter. Adjusted operating margin was 23.9%, compared with 23.4% in the fourth quarter of 2023.

Full Year 2024

Revenue for the full year was $42.88 billion in 2024 versus $42.86 billion in 2023. Organic revenue and Core organic revenue growth were flat.

GAAP Earnings Results

Full year GAAP diluted EPS was $16.53, versus $15.45 in 2023. GAAP operating income for the full year 2024 was $7.34 billion, compared with $6.86 billion in 2023. GAAP operating margin was 17.1%, compared with 16.0% for 2023.

Non-GAAP Earnings Results

Adjusted EPS for the full year 2024 was $21.86, versus $21.55 for 2023. Adjusted operating income for the full year was $9.71 billion, compared with $9.81 billion in 2023. Adjusted operating margin was 22.6%, compared with 22.9% in 2023.

Annual Guidance for 2025

The company will provide 2025 financial guidance during its earnings conference call this morning at 8:30 a.m. Eastern Time.

Use of Non-GAAP Financial Measures

Adjusted EPS, adjusted net income, adjusted operating income, adjusted operating margin, free cash flow, organic revenue growth and Core organic revenue growth are non-GAAP measures that exclude certain items detailed after the tables that accompany this press release, under the heading "Supplemental Information Regarding Non-GAAP Financial Measures." The reconciliations of GAAP to non-GAAP financial measures are provided in the tables that accompany this press release.

Note on Presentation

Certain amounts and percentages reported within this press release are presented and calculated based on underlying unrounded amounts. As a result, the sum of components may not equal corresponding totals due to rounding.

Conference Call

Thermo Fisher Scientific will hold its earnings conference call today, January 30, 2025 at 8:30 a.m. Eastern Time. During the call, the company will discuss its financial performance, as well as future expectations. To listen, call (833) 470-1428 within the U.S. or (404) 975-4839 outside the U.S. The access code is 706921. You may also listen to the call live on the "Investors" section of our website, www.thermofisher.com . The earnings press release and related information can also be found in that section of our website under the heading "Financials". A replay of the call will be available under "News, Events & Presentations" through February 13, 2025.

About Thermo Fisher Scientific

Thermo Fisher Scientific Inc. is the world leader in serving science, with annual revenue over $40 billion. Our Mission is to enable our customers to make the world healthier, cleaner and safer. Whether our customers are accelerating life sciences research, solving complex analytical challenges, increasing productivity in their laboratories, improving patient health through diagnostics or the development and manufacture of life-changing therapies, we are here to support them. Our global team delivers an unrivaled combination of innovative technologies, purchasing convenience and pharmaceutical services through our industry-leading brands, including Thermo Scientific, Applied Biosystems, Invitrogen, Fisher Scientific, Unity Lab Services, Patheon and PPD. For more information, please visit www.thermofisher.com .

Safe Harbor Statement

The following constitutes a "Safe Harbor" statement under the Private Securities Litigation Reform Act of 1995: This press release contains forward-looking statements that involve a number of risks and uncertainties. Important factors that could cause actual results to differ materially from those indicated by forward-looking statements include risks and uncertainties relating to: the need to develop new products and adapt to significant technological change; implementation of strategies for improving growth; general economic conditions and related uncertainties; dependence on customers' capital spending policies and government funding policies; the effect of economic and political conditions and exchange rate fluctuations on international operations; use and protection of intellectual property; the effect of changes in governmental regulations; any natural disaster, public health crisis or other catastrophic event; and the effect of laws and regulations governing government contracts, as well as the possibility that expected benefits related to recent or pending acquisitions, may not materialize as expected. Additional important factors that could cause actual results to differ materially from those indicated by such forward-looking statements are set forth in our most recent annual report on Form 10-K, and subsequent quarterly reports on Form 10-Q, which are on file with the SEC and available in the "Investors" section of our website under the heading "SEC Filings." While we may elect to update forward-looking statements at some point in the future, we specifically disclaim any obligation to do so, even if estimates change and, therefore, you should not rely on these forward-looking statements as representing our views as of any date subsequent to today.

Condensed Consolidated Statements of Income (unaudited)

Three months ended

December 31,

% of

December 31,

% of

(Dollars in millions except per share amounts)

2024

Revenues

2023

Revenues

Revenues

$

11,395

$

10,886

Costs and operating expenses:

Cost of revenues (a)

6,492

57.0

%

6,390

58.7

%

Selling, general and administrative expenses (b)

1,846

16.2

%

1,672

15.4

%

Amortization of acquisition-related intangible assets

438

3.8

%

563

5.2

%

Research and development expenses

374

3.3

%

327

3.0

%

Restructuring and other costs (c)

228

2.0

%

80

0.7

%

Total costs and operating expenses

9,379

82.3

%

9,032

83.0

%

Operating income

2,016

17.7

%

1,854

17.0

%

Interest income

227

309

Interest expense

(316

)

(390

)

Other income/(expense) (d)

14

(33

)

Income before income taxes

1,941

1,740

Benefit from/(provision for) income taxes (e)

(150

)

(133

)

Equity in earnings/(losses) of unconsolidated entities

33

(1

)

Net income

1,824

1,606

Less: net income/(losses) attributable to noncontrolling interests and redeemable noncontrolling interest (f)

(6

)

(24

)

Net income attributable to Thermo Fisher Scientific Inc.

$

1,830

16.1

%

$

1,630

15.0

%

Earnings per share attributable to Thermo Fisher Scientific Inc.:

Basic

$

4.79

$

4.22

Diluted

$

4.78

$

4.20

Weighted average shares:

Basic

382

387

Diluted

383

388

Reconciliation of adjusted operating income and adjusted operating margin

GAAP operating income

$

2,016

17.7

%

$

1,854

17.0

%

Cost of revenues adjustments (a)

22

0.2

%

22

0.2

%

Selling, general and administrative expenses adjustments (b)

16

0.1

%

31

0.3

%

Restructuring and other costs (c)

228

2.0

%

80

0.7

%

Amortization of acquisition-related intangible assets

438

3.8

%

563

5.2

%

Adjusted operating income (non-GAAP measure)

$

2,720

23.9

%

$

2,550

23.4

%

Reconciliation of adjusted net income

GAAP net income attributable to Thermo Fisher Scientific Inc.

$

1,830

$

1,630

Cost of revenues adjustments (a)

22

22

Selling, general and administrative expenses adjustments (b)

16

31

Restructuring and other costs (c)

228

80

Amortization of acquisition-related intangible assets

438

563

Other income/expense adjustments (d)

(11

)

14

Benefit from/(provision for) income taxes adjustments (e)

(138

)

(111

)

Equity in earnings/losses of unconsolidated entities

(33

)

1

Noncontrolling interests adjustments (f)

(14

)

(27

)

Adjusted net income (non-GAAP measure)

$

2,338

$

2,203

Reconciliation of adjusted earnings per share

GAAP diluted EPS attributable to Thermo Fisher Scientific Inc.

$

4.78

$

4.20

Cost of revenues adjustments (a)

0.06

0.06

Selling, general and administrative expenses adjustments (b)

0.04

0.08

Restructuring and other costs (c)

0.60

0.20

Amortization of acquisition-related intangible assets

1.14

1.45

Other income/expense adjustments (d)

(0.03

)

0.04

Benefit from/(provision for) income taxes adjustments (e)

(0.36

)

(0.29

)

Equity in earnings/losses of unconsolidated entities

(0.08

)

0.00

Noncontrolling interests adjustments (f)

(0.04

)

(0.07

)

Adjusted EPS (non-GAAP measure)

$

6.10

$

5.67

Reconciliation of free cash flow

GAAP net cash provided by operating activities

$

3,289

$

3,723

Purchases of property, plant and equipment

(480

)

(405

)

Proceeds from sale of property, plant and equipment

17

11

Free cash flow (non-GAAP measure)

$

2,826

$

3,329

Business Segment Information

Three months ended

December 31,

% of

December 31,

% of

(Dollars in millions)

2024

Revenues

2023

Revenues

Revenues

Life Sciences Solutions

$

2,604

22.9

%

$

2,469

22.7

%

Analytical Instruments

2,186

19.2

%

2,037

18.7

%

Specialty Diagnostics

1,157

10.2

%

1,105

10.2

%

Laboratory Products and Biopharma Services

5,936

52.1

%

5,719

52.5

%

Eliminations

(487

)

-4.3

%

(444

)

-4.1

%

Consolidated revenues

$

11,395

100.0

%

$

10,886

100.0

%

Segment income and segment income margin

Life Sciences Solutions

$

952

36.6

%

$

895

36.2

%

Analytical Instruments

666

30.5

%

587

28.8

%

Specialty Diagnostics

273

23.6

%

264

23.9

%

Laboratory Products and Biopharma Services

828

14.0

%

804

14.0

%

Subtotal reportable segments

2,720

23.9

%

2,550

23.4

%

Cost of revenues adjustments (a)

(22

)

-0.2

%

(22

)

-0.2

%

Selling, general and administrative expenses adjustments (b)

(16

)

-0.1

%

(31

)

-0.3

%

Restructuring and other costs (c)

(228

)

-2.0

%

(80

)

-0.7

%

Amortization of acquisition-related intangible assets

(438

)

-3.8

%

(563

)

-5.2

%

Consolidated GAAP operating income

$

2,016

17.7

%

$

1,854

17.0

%

(a) Adjusted results in 2024 and 2023 exclude charges for the sale of inventory revalued at the date of acquisition and accelerated depreciation on manufacturing assets to be abandoned due to facility consolidations.

(b) Adjusted results in 2024 and 2023 exclude certain third-party expenses, principally transaction/integration costs related to recent acquisitions, charges/credits for changes in estimates of contingent acquisition consideration, and charges associated with product liability litigation. Adjusted results in 2024 also exclude $3 of accelerated depreciation on fixed assets to be abandoned due to facility consolidations.

(c) Adjusted results in 2024 and 2023 exclude restructuring and other costs consisting principally of severance, impairments of long-lived assets, charges for environmental-related matters, net charges/credits for pre-acquisition litigation and other matters, net gains/losses on the sale of real estate, and abandoned facility and other expenses of headcount reductions and real estate consolidations.

(d) Adjusted results in 2024 and 2023 exclude net gains/losses on investments.

(e) Adjusted results in 2024 and 2023 exclude incremental tax impacts for the reconciling items between GAAP and adjusted net income, incremental tax impacts as a result of tax rate/law changes, and the tax impacts from audit settlements. Adjusted results in 2023 also exclude $14 of net charges for pre-acquisition matters.

(f) Adjusted results exclude the incremental impacts for the reconciling items between GAAP and adjusted net income attributable to noncontrolling interests.

Note:

Consolidated depreciation expense is $304 and $276 in 2024 and 2023, respectively.

Organic and Core organic revenue growth

Three months ended

December 31, 2024

Revenue growth

5

%

Acquisitions

1

%

Currency translation

0

%

Organic revenue growth (non-GAAP measure)

4

%

COVID-19 testing revenue

0

%

Core organic revenue growth (non-GAAP measure)

5

%

Note:

For more information related to non-GAAP financial measures, refer to the section titled "Supplemental Information Regarding Non-GAAP Financial Measures" of this release.

Condensed Consolidated Statements of Income (unaudited)

Year ended

December 31,

% of

December 31,

% of

(Dollars in millions except per share amounts)

2024

Revenues

2023

Revenues

Revenues

$

42,879

$

42,857

Costs and operating expenses:

Cost of revenues (a)

24,818

57.9

%

25,295

59.0

%

Selling, general and administrative expenses (b)

7,003

16.3

%

6,569

15.3

%

Amortization of acquisition-related intangible assets

1,952

4.6

%

2,338

5.5

%

Research and development expenses

1,390

3.2

%

1,337

3.1

%

Restructuring and other costs (c)

379

0.9

%

459

1.1

%

Total costs and operating expenses

35,542

82.9

%

35,998

84.0

%

Operating income

7,337

17.1

%

6,859

16.0

%

Interest income

1,078

879

Interest expense

(1,390

)

(1,375

)

Other income/(expense) (d)

12

(65

)

Income before income taxes

7,037

6,298

Benefit from/(provision for) income taxes (e)

(657

)

(284

)

Equity in earnings/(losses) of unconsolidated entities

(42

)

(59

)

Net income

6,338

5,955

Less: net income/(losses) attributable to noncontrolling interests and redeemable noncontrolling interest (f)

3

(40

)

Net income attributable to Thermo Fisher Scientific Inc.

$

6,335

14.8

%

$

5,995

14.0

%

Earnings per share attributable to Thermo Fisher Scientific Inc.:

Basic

$

16.58

$

15.52

Diluted

$

16.53

$

15.45

Weighted average shares:

Basic

382

386

Diluted

383

388

Reconciliation of adjusted operating income and adjusted operating margin

GAAP operating income

$

7,337

17.1

%

$

6,859

16.0

%

Cost of revenues adjustments (a)

47

0.1

%

95

0.2

%

Selling, general and administrative expenses adjustments (b)

(8

)

0.0

%

59

0.1

%

Restructuring and other costs (c)

379

0.9

%

459

1.1

%

Amortization of acquisition-related intangible assets

1,952

4.6

%

2,338

5.5

%

Adjusted operating income (non-GAAP measure)

$

9,707

22.6

%

$

9,810

22.9

%

Reconciliation of adjusted net income

GAAP net income attributable to Thermo Fisher Scientific Inc.

$

6,335

$

5,995

Cost of revenues adjustments (a)

47

95

Selling, general and administrative expenses adjustments (b)

(8

)

59

Restructuring and other costs (c)

379

459

Amortization of acquisition-related intangible assets

1,952

2,338

Other income/expense adjustments (d)

(19

)

50

Benefit from/(provision for) income taxes adjustments (e)

(329

)

(645

)

Equity in earnings/losses of unconsolidated entities

42

59

Noncontrolling interests adjustments (f)

(19

)

(46

)

Adjusted net income (non-GAAP measure)

$

8,380

$

8,364

Reconciliation of adjusted earnings per share

GAAP diluted EPS attributable to Thermo Fisher Scientific Inc.

$

16.53

$

15.45

Cost of revenues adjustments (a)

0.12

0.24

Selling, general and administrative expenses adjustments (b)

(0.02

)

0.15

Restructuring and other costs (c)

0.99

1.18

Amortization of acquisition-related intangible assets

5.09

6.03

Other income/expense adjustments (d)

(0.05

)

0.13

Benefit from/(provision for) income taxes adjustments (e)

(0.86

)

(1.66

)

Equity in earnings/losses of unconsolidated entities

0.11

0.15

Noncontrolling interests adjustments (f)

(0.05

)

(0.12

)

Adjusted EPS (non-GAAP measure)

$

21.86

$

21.55

Reconciliation of free cash flow

GAAP net cash provided by operating activities

$

8,667

$

8,406

Purchases of property, plant and equipment

(1,400

)

(1,479

)

Proceeds from sale of property, plant and equipment

57

87

Free cash flow (non-GAAP measure)

$

7,324

$

7,014

Business Segment Information

Year ended

December 31,

% of

December 31,

% of

(Dollars in millions)

2024

Revenues

2023

Revenues

Revenues

Life Sciences Solutions

$

9,631

22.5

%

$

9,977

23.3

%

Analytical Instruments

7,463

17.4

%

7,263

16.9

%

Specialty Diagnostics

4,512

10.5

%

4,405

10.3

%

Laboratory Products and Biopharma Services

23,157

54.0

%

23,041

53.8

%

Eliminations

(1,885

)

-4.4

%

(1,829

)

-4.3

%

Consolidated revenues

$

42,879

100.0

%

$

42,857

100.0

%

Segment income and segment income margin

Life Sciences Solutions

$

3,503

36.4

%

$

3,420

34.3

%

Analytical Instruments

1,955

26.2

%

1,908

26.3

%

Specialty Diagnostics

1,159

25.7

%

1,124

25.5

%

Laboratory Products and Biopharma Services

3,090

13.3

%

3,358

14.6

%

Subtotal reportable segments

9,707

22.6

%

9,810

22.9

%

Cost of revenues adjustments (a)

(47

)

-0.1

%

(95

)

-0.2

%

Selling, general and administrative expenses adjustments (b)

8

0.0

%

(59

)

-0.1

%

Restructuring and other costs (c)

(379

)

-0.9

%

(459

)

-1.1

%

Amortization of acquisition-related intangible assets

(1,952

)

-4.6

%

(2,338

)

-5.5

%

Consolidated GAAP operating income

$

7,337

17.1

%

$

6,859

16.0

%

(a) Adjusted results in 2024 and 2023 exclude charges for inventory write-downs associated with large-scale abandonment of product lines, accelerated depreciation on manufacturing assets to be abandoned due to facility consolidations, and charges for the sale of inventory revalued at the date of acquisition.

(b) Adjusted results in 2024 and 2023 exclude certain third-party expenses, principally transaction/integration costs related to recent acquisitions, charges/credits for changes in estimates of contingent acquisition consideration, and charges associated with product liability litigation. Adjusted results in 2024 also exclude $7 of accelerated depreciation on fixed assets to be abandoned due to facility consolidations.

(c) Adjusted results in 2024 and 2023 exclude restructuring and other costs consisting principally of severance, impairments of long-lived assets, charges for environmental-related matters, net charges for pre-acquisition litigation and other matters, net gains/losses on the sale of real estate, and abandoned facility and other expenses of headcount reductions and real estate consolidations. Adjusted results in 2023 also exclude $26 of contract termination costs associated with facility closures.

(d) Adjusted results in 2024 and 2023 exclude net gains/losses on investments.

(e) Adjusted results in 2024 and 2023 exclude incremental tax impacts for the reconciling items between GAAP and adjusted net income, incremental tax impacts as a result of tax rate/law changes and the tax impacts from audit settlements. Adjusted results in 2023 also exclude $14 of net charges for pre-acquisition matters.

(f) Adjusted results exclude the incremental impacts for the reconciling items between GAAP and adjusted net income attributable to noncontrolling interests.

Notes:

Consolidated depreciation expense is $1,156 and $1,068 in 2024 and 2023, respectively.

For more information related to non-GAAP financial measures, refer to the section titled "Supplemental Information Regarding Non-GAAP Financial Measures" of this release.

Organic and Core organic revenue growth

Year ended

December 31, 2024

Revenue growth

0

%

Acquisitions

0

%

Currency translation

0

%

Organic revenue growth (non-GAAP measure)

0

%

COVID-19 testing revenue

-1

%

Core organic revenue growth (non-GAAP measure)

0

%

Note:

For more information related to non-GAAP financial measures, refer to the section titled "Supplemental Information Regarding Non-GAAP Financial Measures" of this release.

Condensed Consolidated Balance Sheets (unaudited)

December 31,

December 31,

(In millions)

2024

2023

Assets

Current assets:

Cash and cash equivalents

$

4,009

$

8,077

Short-term investments

1,561

3

Accounts receivable, net

8,191

8,221

Inventories

4,978

5,088

Other current assets

3,399

3,200

Total current assets

22,137

24,589

Property, plant and equipment, net

9,306

9,448

Acquisition-related intangible assets, net

15,533

16,670

Other assets

4,492

3,999

Goodwill

45,853

44,020

Total assets

$

97,321

$

98,726

Liabilities, redeemable noncontrolling interest and equity

Current liabilities:

Short-term obligations and current maturities of long-term obligations

$

2,214

$

3,609

Other current liabilities

11,118

10,403

Total current liabilities

13,332

14,012

Other long-term liabilities

5,257

6,564

Long-term obligations

29,061

31,308

Redeemable noncontrolling interest

120

118

Total equity

49,551

46,724

Total liabilities, redeemable noncontrolling interest and equity

$

97,321

$

98,726

Condensed Consolidated Statements of Cash Flows (unaudited)

Year ended

December 31,

December 31,

(In millions)

2024

2023

Operating activities

Net income

$

6,338

$

5,955

Adjustments to reconcile net income to net cash provided by operating activities:

Depreciation and amortization

3,108

3,406

Change in deferred income taxes

(1,209

)

(1,300

)

Other non-cash expenses, net

808

882

Changes in assets and liabilities, excluding the effects of acquisitions

(379

)

(537

)

Net cash provided by operating activities

8,667

8,406

Investing activities

Purchases of property, plant and equipment

(1,400

)

(1,479

)

Proceeds from sale of property, plant and equipment

57

87

Proceeds from cross-currency interest rate swap interest settlements

252

70

Acquisitions, net of cash acquired

(3,132

)

(3,660

)

Purchases of investments

(3,396

)

(208

)

Proceeds from sales and maturities of investments

1,770

15

Other investing activities, net

8

33

Net cash used in investing activities

(5,841

)

(5,142

)

Financing activities

Net proceeds from issuance of debt

1,204

5,942

Repayment of debt

(3,607

)

(5,782

)

Proceeds from issuance of commercial paper

—

1,620

Repayment of commercial paper

—

(1,935

)

Purchases of company common stock

(4,000

)

(3,000

)

Dividends paid

(583

)

(523

)

Other financing activities, net

195

56

Net cash used in financing activities

(6,792

)

(3,622

)

Exchange rate effect on cash

(91

)

(82

)

Decrease in cash, cash equivalents and restricted cash

(4,057

)

(440

)

Cash, cash equivalents and restricted cash at beginning of period

8,097

8,537

Cash, cash equivalents and restricted cash at end of period

$

4,040

$

8,097

Free cash flow (non-GAAP measure)

$

7,324

$

7,014

Note:

For more information related to non-GAAP financial measures, refer to the section titled "Supplemental Information Regarding Non-GAAP Financial Measures" of this release.

Supplemental Information Regarding Non-GAAP Financial Measures

In addition to the financial measures prepared in accordance with generally accepted accounting principles (GAAP), we use certain non-GAAP financial measures such as organic revenue growth, which is reported revenue growth, excluding the impacts of acquisitions/divestitures and the effects of currency translation. We also report Core organic revenue growth, which is reported revenue growth, excluding the impacts of COVID-19 testing revenue, and excluding the impacts of acquisitions/divestitures and the effects of currency translation. We report these measures because Thermo Fisher management believes that in order to understand the company's short-term and long-term financial trends, investors may wish to consider the impact of acquisitions/divestitures, foreign currency translation and/or COVID-19 testing on revenues. Thermo Fisher management uses these measures to forecast and evaluate the operational performance of the company as well as to compare revenues of current periods to prior periods.

We report adjusted operating income, adjusted operating margin, adjusted net income, and adjusted EPS. We believe that the use of these non-GAAP financial measures, in addition to GAAP financial measures, helps investors to gain a better understanding of our core operating results and future prospects, consistent with how management measures and forecasts the company's core operating performance, especially when comparing such results to previous periods, forecasts, and to the performance of our competitors. Such measures are also used by management in their financial and operating decision-making and for compensation purposes. To calculate these measures we exclude, as applicable:

  • Certain acquisition-related costs, including charges for the sale of inventories revalued at the date of acquisition, significant transaction/acquisition-related costs, including changes in estimates of contingent acquisition-related consideration, and other costs associated with obtaining short-term financing commitments for pending/recent acquisitions. We exclude these costs because we do not believe they are indicative of our normal operating costs.
  • Costs/income associated with restructuring activities and large-scale abandonments of product lines, such as reducing overhead and consolidating facilities. We exclude these costs because we believe that the costs related to restructuring activities are not indicative of our normal operating costs.
  • Equity in earnings/losses of unconsolidated entities; impairments of long-lived assets; and certain other gains and losses that are either isolated or cannot be expected to occur again with any predictability, including gains/losses on investments, the sale of businesses, product lines, and real estate, significant litigation-related matters, curtailments/settlements of pension plans, and the early retirement of debt. We exclude these items because they are outside of our normal operations and/or, in certain cases, are difficult to forecast accurately for future periods.
  • The expense associated with the amortization of acquisition-related intangible assets because a significant portion of the purchase price for acquisitions may be allocated to intangible assets that have lives of up to 20 years. Exclusion of the amortization expense allows comparisons of operating results that are consistent over time for both our newly acquired and long-held businesses and with both acquisitive and non-acquisitive peer companies.
  • The noncontrolling interest and tax impacts of the above items and the impact of significant tax audits or events (such as changes in deferred taxes from enacted tax rate/law changes), the latter of which we exclude because they are outside of our normal operations and difficult to forecast accurately for future periods.

We report free cash flow, which is operating cash flow excluding net capital expenditures, to provide a view of the continuing operations' ability to generate cash for use in acquisitions and other investing and financing activities. The company also uses this measure as an indication of the strength of the company. Free cash flow is not a measure of cash available for discretionary expenditures since we have certain non-discretionary obligations such as debt service that are not deducted from the measure.

Thermo Fisher Scientific does not provide GAAP financial measures on a forward-looking basis because we are unable to predict with reasonable certainty and without unreasonable effort items such as the timing and amount of future restructuring actions and acquisition-related charges as well as gains or losses from sales of real estate and businesses, the early retirement of debt and the outcome of legal proceedings. The timing and amount of these items are uncertain and could be material to Thermo Fisher Scientific's results computed in accordance with GAAP.

The non-GAAP financial measures of Thermo Fisher Scientific's results of operations and cash flows included in this press release are not meant to be considered superior to or a substitute for Thermo Fisher Scientific's results of operations prepared in accordance with GAAP. Reconciliations of such non-GAAP financial measures to the most directly comparable GAAP financial measures are set forth in the tables above.

Media Contact Information:
Sandy Pound
Thermo Fisher Scientific
Phone: 781-622-1223
E-mail: sandy.pound@thermofisher.com

Investor Contact Information:
Rafael Tejada
Thermo Fisher Scientific
Phone: 781-622-1356
E-mail: rafael.tejada@thermofisher.com

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Orchestra BioMed Holdings, Inc. (Nasdaq: OBIO, "Orchestra BioMed" or the "Company"), a biomedical company accelerating high-impact technologies to patients through risk-reward sharing partnerships, today announced financial results for the first quarter ended March 31, 2025, and provided a business update highlighting continued regulatory momentum, disciplined operational execution, and a strengthening clinical development pipeline.

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Medtronic will host a video webcast at 7:00 a.m. CDT on May 21, 2025 , to discuss results for its fourth quarter and full fiscal year 2025. The webcast can be accessed at https://investorrelations.medtronic.com .

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(PRNewsfoto/Medtronic plc)

Sphere-360 Study Safety and Performance

Sphere-360 is an investigational, first-of-its-kind, single-shot PFA mapping and ablation catheter for treatment of paroxysmal atrial fibrillation (PAF). Results for Sphere-360 at one year, in a prospective, single-arm, multi-center trial performed in European centers, demonstrated freedom from arrhythmia recurrence in 88% of patients, with chronically durable pulmonary vein isolation (PVI) in 98% of targeted veins and no reported safety events in a sub-group treated with the most optimized waveform. The Sphere-360 catheter has a large, conformable lattice design that can be modified into various shapes, is seamlessly integrated with the Affera Mapping and Ablation System and utilizes an 8.5 Fr sheath – the smallest in any single-shot PFA technology.

"The Affera technology is a sophisticated ecosystem, including an advanced, intuitive mapping system and catheters that are seamlessly integrated to offer treatment options for different cardiac arrhythmias. It is encouraging to see the promising results for Sphere-360, which can easily create circumferential lesions without the need for catheter rotation," said Vivek Reddy , M.D., Director of Cardiac Arrhythmia Services for the Mount Sinai Health System in New York City . "The study results showed Sphere-360 has a promising safety and performance profile with zero serious adverse events observed. Upon approval, Sphere-360 will be a valuable addition to Medtronic's Affera system, which has been a game changer for Afib treatment and physician workflow."

Medtronic intends to begin its U.S. pivotal trial for the Sphere-360 catheter later this calendar year. Worldwide, Sphere-360 is currently investigational and not approved for sale or distribution.

Sphere-9 for Linear Ablation

Additionally, in a sub-analysis from the Sphere Per-AF IDE study , results demonstrated that the Sphere-9 catheter can be used safely and effectively to create linear lesions in persistent AF patients. Linear ablation is often used in conjunction with PVI to improve the chances of restoring a normal heart rhythm without recurrence in persistent AF patients. The Sphere Per-AF IDE study evaluated the safety, efficacy and efficiency of Affera and Sphere-9 in persistent AF and led to the FDA approval of Affera in October 2024 .

"True to our Medtronic mission for patients and legacy of innovation, we are delivering our best-in-class technologies to physicians and improving care for AFib patients, and we are not slowing down," said Rebecca Seidel , president of the Cardiac Ablation Solutions business at Medtronic, which is part of the Cardiovascular portfolio. "These results signify another step forward and energize us as we continue to earn and build our leadership position in electrophysiology every day."

Medtronic is the only company with two PFA offerings for physicians and patients. The PulseSelectâ„¢ Pulsed Field Ablation System offers physicians a safe, single-shot solution for pulmonary vein isolation (PVI) and is now available in more than 30 countries. The Affera system together with the Sphere-9 catheter enables physician treatment flexibility with its wide area focal design and 9mm lattice tip that can used with an 8.5Fr sheath. Affera is available in Europe , Australia and New Zealand , with global expansion ongoing.

AFib is one of the most common and undertreated heart rhythm disorders, affecting more than 60 million people worldwide. 1 Afib is a progressive disease, often beginning as paroxysmal AFib (presents intermittently) and progressing to persistent (lasts for more than 7+ days without stopping). As the disease progresses, the risk of serious complications including heart failure, stroke and risk of death increases 2-5 .

For more information on the Affera PFA system and the Sphere-9 catheter, visit Medtronic.com.

About Medtronic

Bold thinking. Bolder actions. We are Medtronic. Medtronic plc, headquartered in Galway , Ireland , is the leading global healthcare technology company that boldly attacks the most challenging health problems facing humanity by searching out and finding solutions. Our Mission — to alleviate pain, restore health, and extend life — unites a global team of 95,000+ passionate people across more than 150 countries. Our technologies and therapies treat 70 health conditions and include cardiac devices, surgical robotics, insulin pumps, surgical tools, patient monitoring systems, and more. Powered by our diverse knowledge, insatiable curiosity, and desire to help all those who need it, we deliver innovative technologies that transform the lives of two people every second, every hour, every day. Expect more from us as we empower insight-driven care, experiences that put people first, and better outcomes for our world. In everything we do, we are engineering the extraordinary. For more information on Medtronic (NYSE: MDT), visit www.Medtronic.com and follow Medtronic on LinkedIn .

Any forward-looking statements are subject to risks and uncertainties such as those described in Medtronic's periodic reports on file with the Securities and Exchange Commission. Actual results may differ materially from anticipated results.

References

  1. Roth GA, Mensah GA, Johnson CO et al. Global Burden of Cardiovascular Diseases and Risk Factors, 1990-2019: Update From the GBD 2019 Study. J Am Coll Cardiol 2020;76:2982-3021.
  2. Miyasaka Y, Barnes ME, Bailey KR, et al. Mortality trends in patients diagnosed with first atrial fibrillation: a 21-year community-based study. J Am Coll Cardiol 2007;49:986-92.
  3. Hindricks G, Potpara T, Dagres N, et al. 2020 ESC Guidelines for the diagnosis and management of atrial fibrillation developed in collaboration with the European Association of Cardio-Thoracic Surgery (EACTS). Eur Heart J 2020.
  4. Wolf PA , Abbott RD, Kannel WB. Atrial fibrillation as an independent risk factor for stroke: the Framingham Study. Stroke 1991;22:983-8.
  5. Lubitz SA, Moser C, Sullivan L, et al. Atrial fibrillation patterns and risks of subsequent stroke, heart failure, or death in the community. J Am Heart Assoc 2013;2:e000126

Dr. Reddy is a paid consultant for Medtronic.

Contacts:
Leslie Williamson
Public Relations
+1-612-227-5099

Ryan Weispfenning
Investor Relations
+1-763-505-4626

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SOURCE Medtronic plc

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