Medical Device

In a release issued under the same headline on Friday, November 13, by Avricore Health Inc. (TSXV: AVCR), the units issued figure was meant to be 6,260,000, not 6,360,000. The corrected release follows:

A VRICORE HEALTH INC. (TSXV: AVCR) (the "Company" or "A vricore " ) announces it has closed the first tranche of its non-brokered private placement for gross proceeds of $626,000. The Company will issue 6,260,000 units at $0.10 per unit and will pay finders fees totaling $22,500 and issue 225,000 finders warrants. Insiders participated in the aggregate amount of $55,000 for 550,000 units. Placement proceeds will be used for general working capital purposes.

"Despite a very challenging year, our company continues to march down the field in a positive way and we are really pleased to not only be able to raise capital, but also raise it at a premium," said Avricore Health CEO, Hector Bremner. "While the decision horizon for some investors is further out than this first group, we are confident in the enthusiasm and momentum we have to close out the balance."

Each Unit consists of one common share and one transferrable share purchase warrant. Each warrant will entitle the holder thereof to purchase one additional common share for a period of 12 months from the closing date of the offering at a price of $0.15 per common share provided that if the closing price of the common shares of the Company on any stock exchange or quotation system on which the common shares are then listed or quoted is equal to or greater than $0.20 for a period of fifteen (15) consecutive trading days, the Company will have the right to accelerate the expiry of the warrants to a date that is not less than ten (10) business days from the date notice is given. The Company may pay finders fees of up to 5% cash and 5% finders warrants on a portion of the placement.

Closing of the Private Placement is subject to final acceptance by the TSX Venture Exchange. All securities issued in connection with the Private Placement will be subject to a four-month hold period from the closing date under applicable Canadian securities laws.

The Private Placement securities have not been and will not be registered under the U.S. Securities Act of 1933, as amended (the "1933 Act"), or under any state securities laws, and may not be offered or sold, directly or indirectly, or delivered within the United States or to, or for the account or benefit of, U.S. persons (as defined in Regulation S under the 1933 Act) absent registration or an applicable exemption from the registration requirements. This news release does not constitute an offer to sell or a solicitation to buy such securities in the United States.


Hector Bremner, CEO 604-773-8943

About Avricore Health Inc.
Avricore Health Inc. is committed to becoming a health innovator and applying technologies at the forefront of science to core health issues at the community pharmacy level. The Company's goal is to empower consumers, patients and pharmacists with innovative technology, products, services and information to monitor and optimize health.

Neither the TSX Venture Exchange nor its Regulation Services Provider (as that term is defined in the policies of the TSX Venture Exchange) accepts responsibility for the adequacy or accuracy of this release.

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Bausch Health Provides Update Following Oral Order in XIFAXAN® Patent Litigation

-- Company to Appeal Expected Court Decision on Certain XIFAXAN® Patents –

Bausch Health Companies Inc. (NYSETSX: BHC), and its gastroenterology business Salix Pharmaceuticals, today announced the U.S. District Court of Delaware issued an Oral Order in the matter of Salix Pharmaceuticals, Ltd. et al v. Norwich Pharmaceuticals, Inc. regarding the infringement and validity of certain U.S. Patents protecting the composition and use of XIFAXAN® (rifaximin) 550 mg tablets for the treatment of irritable bowel syndrome with diarrhea (IBS-D) and reduction in risk of overt hepatic encephalopathy (HE) recurrence.

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IIROC Trade Resumption - BHC

Trading resumes in:

Company: Bausch Health Companies Inc.

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Thermo Fisher Scientific Reports Second Quarter 2022 Results

Thermo Fisher Scientific Inc. (NYSE: TMO), the world leader in serving science, today reported its financial results for the second quarter ended July 2, 2022.

Second Quarter 2022 Highlights

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Bausch Health Companies Inc. Will Release Second-Quarter 2022 Financial Results on Aug. 9

Bausch Health Companies Inc. (NYSETSX: BHC) ("Bausch Health") will release its second-quarter financial results on Tuesday, Aug. 9, 2022 . Bausch Health will host a conference call and live web cast at 8:00 a.m. ET to discuss the results and provide a business update. All materials will be made available on the Investor Relations section of the Bausch Health website prior to the start of the call.

Conference Call Details

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Abbott Introduces Canada's First Remote Neuromodulation Patient-Care Technology, NeuroSphere Virtual Clinic, to Treat People with Chronic Pain and Movement Disorders*

  • The new system allows patients implanted with an Abbott neuromodulation device to communicate with their physician and remotely receive treatment in real time, regardless of location §

Abbott (NYSE: ABT) announces the Health Canada licencing† of NeuroSphere™ Virtual Clinic, a remote programming technology that is the first of its kind in Canada and is compatible with Abbott's suite of neuromodulation technologies. NeuroSphere Virtual Clinic has the potential to increase access to optimal treatment for patients living with chronic pain, Parkinson's disease, or essential tremors who might otherwise have difficulty receiving care from their healthcare provider due to location or being unable to travel to seek care.

Sample screen view of a patient-physician interaction on Abbott's NeuroSphere Virtual Clinic

Abbott's NeuroSphere Virtual Clinic gives patients the flexibility and comfort of receiving care anywhere § by connecting with their doctor via secure in-app video chat and an integrated remote programming feature. This feature enables clinicians to prescribe new treatment settings remotely to the patient's neurostimulation device using the clinician programmer app and a new, simple, and secure remote care connection.

In Canada , it is estimated that more than 6 million people live with chronic pain, 1 almost 100,000 people live with Parkinson's disease, 2 and almost 2 million people live with an essential tremor. 3 , 4 Many of these people who don't live close to a healthcare centre have difficulty accessing care due to the inability to see their doctor in-person. They are often challenged by the time associated with the trip, and/or the availability of a caregiver to help with their travel. In addition to the time implications, patients and caregivers may experience considerable travel-related costs and reduced employment wages. This is particularly true for those living in rural, northern, and remote parts of the country. 5

"Without alternatives to in-person programming, many of these patients may delay or forego care, particularly those who face a travel burden," said Alfonso Fasano , M.D., Ph.D., with Krembil Brain Institute at Toronto Western Hospital, part of the University Health Network. "Fortunately, innovative virtual healthcare options are changing the treatment landscape, ultimately extending care beyond clinic walls. Remote programming is an important new option that allows patients to communicate with their physicians virtually to ensure proper device settings and functionality. This brings the convenience of connected care to neurostimulation therapy, giving patients the ability to manage their therapy in a way that fits their personal needs."

NeuroSphere Virtual Clinic is compatible with the following Canadian-licensed Abbott neuromodulation devices: **

  • Proclaim™ spinal cord stimulation (SCS), for the management of chronic, intractable pain of the trunk and/or limbs
  • Proclaim dorsal root ganglion (DRG) therapy, for the management of moderate to severe chronic intractable pain of the lower limbs
  • Infinity™ deep brain stimulation (DBS) therapy, for the management of Parkinson's disease and tremor

"For more than a decade, Abbott has been evaluating the treatment hurdles neuromodulation patients faced," said Pedro Malha, vice president, neuromodulation, Abbott. "During this time, we have diligently worked to find better ways of connecting patients to their doctors. The launch of NeuroSphere Virtual Clinic in Canada exemplifies Abbott's ability to put science and innovation to work, delivering solutions to help people live their best lives."

The ongoing evolution of Abbott neuromodulation technologies highlights the commitment to patient-centered research integrated with cutting-edge technologies to go beyond physical symptom relief and improve the lives of people with neurological disorders. Abbott's NeuroSphere Virtual Clinic was first launched in the United States in March 2021 .

*Neurostimulation systems for DBS are used in patients with levodopa-responsive Parkinson's disease or tremor. Please refer to the device Instructions for Use for details.

§ Anywhere with a cellular or Wi-Fi connection and sufficiently charged patient controller.

†The St. Jude Medical Clinician Programmer App and St. Jude Medical Patient Controller App used with the NeuroSphere Virtual Clinic are currently licensed.

**Certain configurations of the devices within may not have been licensed in accordance with Canadian law. Contact your local sales representative for the regulatory status of the device(s) in Canada . This product is intended for use by or under the direction of a physician. Prior to use, reference the Instructions for Use, inside the product carton (when available) or at for more detailed information on Indications, Contraindications, Warnings, Precautions and Adverse Events as applicable to Canada .

About Neuromodulation
Neuromodulation is an advanced personalized treatment option often recommended for patients who suffer from chronic pain and certain movement disorders, such as Parkinson's disease and essential tremors. Abbott neuromodulation systems use a recharge-free implanted generator, and a thin wire called a lead to send mild electrical pulses to areas of the brain that cause pain or tremors. These pulses interrupt the signals responsible for these symptoms. 6

About Abbott
Abbott is a global healthcare leader that helps people live more fully at all stages of life. Our portfolio of life-changing technologies spans the spectrum of healthcare, with leading businesses and products in diagnostics, medical devices, nutritionals and branded generic medicines. Our 113,000 colleagues serve people in more than 160 countries.

Connect with us at , on LinkedIn at , on Facebook at and on Twitter @AbbottNews.

1 Prevalence of chronic pain among individuals with neurological conditions. Statistics Canada . Updated March 21, 2018 . Accessed on May 25, 2022 .
2 About Parkinson's Disease. Parkinson's Canada . Accessed on May 25, 2022 .
3 Agarwal, S. (2020, July 14 ). Essential Tremor. Access on May 25, 2022 .
4 Canada's population estimates: Age and sex, July 1, 2021 . Statistics Canada . Updated September 29, 2022 . Accessed May 25, 2022 .
5 Publicly funded medical travel subsidy programs in Canada . Canadian Social Work Review. Volume 34, Number 1, 2017, p. 123–139. Accessed May 24, 2022 .
6 Yu, H., & Neimat, J. (2008). The treatment of movement disorders by deep brain stimulation. Neurotherapeutics , 5, 26-36 .

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Beckman Coulter Partners with Mass General and BARDA to Identify Severe Pediatric Infections in Emergency Departments

Beckman Coulter, global leader in advanced diagnostics, today announced that it will partner with Massachusetts General Hospital to validate the use of the novel Monocyte Distribution Width (MDW) hematology biomarker in rapid identification of children presenting with early signs of severe illness from infection.

Beckman Coulter partners with Mass General and BARDA to validate the use of the novel Monocyte Distribution Width (MDW) hematology biomarker in rapid identification of children presenting with early signs of severe illness from infection.

This pivotal, multi-center trial will receive funding from the Biomedical Advanced Research and Development Authority (BARDA), part of the office of the Assistant Secretary for Preparedness and Response at the U.S. Department of Health and Human Services. MDW is currently the only FDA-cleared blood biomarker to aid in detecting adult sepsis in the Emergency Department (ED). This current partnership aims to expand the utility of MDW as a screening tool to measure the severity of infection in children 15 years old and younger presenting with high fevers.

Approximately 25 million children under 15 visit the emergency room every year, and about one in five presents with a fever. 1 The most common cause of fever in these children is infections that can be safely treated at home; however, one out of every four pediatric hospital admissions are due to complications from infection. 2 No objective biomarker yet exists that accurately identifies children at risk of hospitalization from an excessive immune response early in the infectious course when intervention is critical, making clinical decisions in the ED on how to treat pediatric infections difficult.

"A sick, febrile child can be challenging to examine, and current blood tests have limited ability to predict who will progress to acute illness," states Lael Yonker , M.D., a pediatric pulmonologist at Mass General for Children, and co-investigator on this clinical trial.  "Objective tests that are readily available are needed to make sure children get the medical attention they need in a timely manner."

The utility of MDW as a biomarker in pediatric infection was first recognized by Mass General during the height of the COVID-19 pandemic, when more than 400 children a month were developing a life-threatening complication from COVID-19, now termed Multisystem Inflammatory Syndrome in Children (MIS-C).

As published in June 2022 in BMC Infectious Diseases 3 , the team found that MDW can improve the identification of children at high risk of MIS-C complication, a task that has proven challenging to clinicians. 4 Now, this team will join Beckman Coulter and BARDA to potentially expand the use of MDW in the early recognition of severe infections in children presenting to EDs.

Notably, this tool is based on routinely ordered blood tests and can be reported as an additional parameter on Complete Blood Count (CBC) results. This approach may allow ED physicians to make rapid, accurate and safe decisions about which children with infections can go home and which children with infections need to be admitted to the hospital for further treatment without subjecting patients to additional and costly testing.

"We are thrilled to be partnering with pediatricians at Mass General to investigate the utility of MDW in identifying children at risk of adverse outcomes due to infection," said Julie Sawyer Montgomery , president, Beckman Coulter. "Along with the award from BARDA, Beckman Coulter is committing additional funds to this partnership. We are invested in establishing the performance of MDW in the pediatric population and in continuing our commitment to clinical evidence for use of MDW, and other novel hematological biomarkers."

MDW is a regulatory-cleared parameter for adult patients presenting to the ED and is available as a standard component of a CBC performed on Beckman Coulter's DxH 900 and 690T hematology analyzers. The MDW parameter measures the dispersion of monocyte volume in the blood, which is altered during infection due to monocyte activation and subsequent changes in monocyte morphology. Increases in MDW indicate increases in the variability of monocyte morphology, which can indicate a progression from localized to systemic infection.

MDW provides physicians with an early indication of sepsis risk, which is especially important when a patient's symptoms are mild and alternative diagnoses are being considered. MDW is only available on Beckman Coulter platforms.

This project has been funded in whole or in part with federal funds from the Department of Health and Human Services; Office of the Assistant Secretary for Preparedness and Response; Biomedical Advanced Research and Development Authority, under contract number 75A50122C00036.

Follow and connect with Beckman Coulter via LinkedIn , Twitter , and Facebook

About Beckman Coulter. Inc.

A global leader in advanced diagnostics, Beckman Coulter has challenged convention to elevate the diagnostic laboratory's role in improving patient health for more than 80 years. Our mission is to Relentlessly Reimagine Healthcare, One Diagnosis at a Time – and we do this by applying the power of science, technology and the passion and creativity of our teams. Our diagnostic solutions are used in complex clinical testing, and are found in hospitals, reference laboratories and physician office settings around the globe. We exist to deliver smarter, faster diagnostic solutions that move the needle forward from what's now to what's next. We do this by accelerating care with an extensive clinical menu, scalable lab automation technologies, insightful clinical informatics, and optimize lab performance services. Beckman Coulter is part of the Danaher Corporation (NYSE:DHR) family of global science and technology companies. Headquartered in Brea, Calif. , it has more than 11,000 global team members.

  1. Cairns C, Kang K, Santo L. National Hospital Ambulatory Medical Care Survey: 2018 emergency department summary tables. Available from: FastStats - Emergency Department Visits (
  2. Goto T, Tsugawa Y, Mansbach JM, Camargo CA Jr, Hasegawa K. Trends in Infectious Disease Hospitalizations in US Children, 2000 to 2012. Pediatr Infect Dis J . 2016;35(6):e158-e163. doi:10.1097/INF.0000000000001134
  3. Yonker LM, Badaki-Makun O, Arya P, Boribong BP, Moraru G, Fenner B, Rincon J, Hopke A, Rogers B, Hinson J, Fasano A, Lee L, Kehoe SM, Larson SD, Chavez H, Levin S, Moldawer LL, Irimia D. Monocyte anisocytosis increases during multisystem inflammatory syndrome in children with cardiovascular complications. BMC Infect Dis . 2022;22(1):563. doi: 10.1186/s12879-022-07526-9.
  4. Rosu CA, Martens AM, Sumner J, Farkas EJ, Arya P, Arauz AB, Madhavan VL, Chavez H, Larson SD, Badaki-Makun O, Irimia D, Yonker LM. Heterogeneity in the evaluation of suspected MIS-C: a cross-sectional vignette-based survey . BMC Pediatr . 2022;22(1):392. doi: 10.1186/s12887-022-03446-4.

© 2022 Beckman Coulter. All rights reserved. Beckman Coulter, the stylized logo, and the Beckman Coulter product and service marks mentioned herein are trademarks or registered trademarks of Beckman Coulter, Inc. in the United States and other countries. 2022-10652

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