Danaher Announces Renowned Scientists To Join New Scientific Advisory Board

- Danaher Corporation (NYSE: DHR) ("Danaher"), the global science and technology company, announced today the formation of a Scientific Advisory Board ("Board") to support its innovation and investment strategy.

The Board will help the company protect and grow existing scientific innovations, support its development of new technologies and bring unique perspectives to rapidly emerging science and technology trends impacting Danaher.

The Board is comprised of preeminent scientists, including two Nobel laureates, with global experience and research expertise across all areas of health sciences. The Board will work with Danaher's executive leadership team and its Board of Directors to assess opportunities for M&A and to prioritize early-stage investments in strategic areas.  They will also be tasked with collaborating with Danaher's own scientific community to create proprietary insights and develop promising innovations to support customers.

Rainer Blair , Danaher President & CEO, said: "An important part of Danaher's competitive advantage and key to our long-term success is the innovative expertise that we bring to bear on our customers' most pressing global health and safety needs. The scientists who have generously agreed to join our Scientific Advisory Board will play an inspirational role, working closely alongside our own teams to challenge, validate and guide our scientific agenda – aligning our priorities with our customers' and the world's ever-evolving needs."

"We are at a critical inflection point in the acceleration of science and technology," added JC Gutiérrez-Ramos, Danaher Chief Science Officer. "We are witnessing the convergence of scientific disciplines hastening opportunities to affect human health at scale, increase access to health care, reduce suffering and improve health outcomes around the world.  At Danaher, we are pleased to have such an esteemed group of minds partnering with us to envision and shape that future."

Members of the Danaher Scientific Advisory Board are:

  • Angela Caliendo , M.D., Ph.D. Warren Alpert Foundation Professor of Medicine and Executive Vice Chair of Medicine at Alpert Medical School of Brown University ; and President of Brown Physicians, Inc. Molecular Infectious diseases specialist with global reputation.
  • James J. Collins , Ph.D. Termeer Professor of Bioengineering in the Department of Biological Engineering and Institute for Medical Engineering & Science. Leader in synthetic biology and systems biology, with a focus on applying network biology approaches to study antibiotic action, bacterial defense mechanisms, and antibiotic resistance.
  • Robert Hershberg , M.D., Ph.D. Venture Partner at Frazier Healthcare Partners. Expert in the fields of immuno-oncology and translational medicine, with a passion for the advancement of early cancer screening technologies.
  • Isaac S. Kohane , M.D., Ph.D. Marion V. Nelson Professor of Biomedical Informatics, Harvard Medical School ; Chair of the Department of Biomedical Informatics, Harvard Medical School ; and Associate Professor of Medicine, Brigham and Women's Hospital. Expert in application of data – including AI – to derive new diagnoses and deliver the best care available more rapidly.
  • Amy Lynn McGuire , J.D., Ph.D. Leon Jaworski Professor of Biomedical Ethics and Director of the Center for Medical Ethics and Health Policy at Baylor College of Medicine . Expert in the clinical integration of emerging technologies, with a focus on ethical and policy issues in human genetics and genomic research.
  • David Rimm , M.D., Ph.D. Professor of Pathology and of Medicine, Director of Pathology Tissue Services, and Director of Translational Pathology, Yale School of Medicine . Specializes in Immuno-Oncology, Molecular Pathology methods including NGS and has a strong background with AI-based image analysis in Pathology.
  • Phillip A. Sharp , Ph.D. & Nobel Prize Laureate Institute Professor and Professor of Biology, MIT , and Member, Koch Institute for Integrative Cancer Research. Pioneer in the molecular biology of the mechanisms of RNA splicing and its implication for cancer.
  • Thomas C. Südhof, M.D. & Nobel Prize Laureate Avram Goldstein Professor Investigator, Howard Hughes Medical Institute; Professor, Dept. of Molecular & Cellular Physiology and of Neurosurgery, Professor (by courtesy), Dept. of Neurology & Neurological Sciences and of Psychiatry & Behavioral Science, Stanford Medicine . Pioneer in the study of how synapses work including the molecular basis for neuroscience and brain chemistry.
  • David R. Walt , Ph.D. Hansjörg Wyss Professor of Biologically Inspired Engineering, Harvard Medical School ; Professor of Pathology at Brigham and Women's Hospital; Core Faculty of the Wyss Institute at Harvard University ; and Howard Hughes Medical Institute Professor. Founder of Illumina and Quanterix. Pioneered the use of microwells for the analysis of DNA, RNA and proteins, which revolutionized the field.

For more information on the Scientific Advisory Board, visit: https://www.danaher.com/who-we-are/leadership-team .

ABOUT DANAHER
Danaher is a global science and technology innovator committed to helping its customers solve complex challenges and to improving quality of life around the world. Its family of world-class brands has leadership positions in the demanding and attractive health care, environmental and applied end-markets. With more than 20 operating companies, Danaher's globally diverse team of approximately 69,000 associates is united by a common culture and operating system, the Danaher Business System, and its Shared Purpose, Helping Realize Life's Potential .

For more information on Danaher, please visit www.danaher.com .

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SOURCE Danaher Corporation

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Medtronic advances Abbott CGM partnership with FDA submission of interoperable insulin pump

Medtronic advances Abbott CGM partnership with FDA submission of interoperable insulin pump

Medtronic plc (NYSE: MDT), a global leader in healthcare technology, today announced it has submitted 510(k) applications to the U.S. Food and Drug Administration (FDA) seeking clearance for an interoperable pump. FDA clearance of this pump would pave the way for system integration with a continuous glucose monitoring (CGM) sensor based on Abbott's most advanced CGM platform.

(PRNewsfoto/Medtronic plc)

The submissions included a 510(k) application for its MiniMed™ 780G pump as an alternate controller enabled (ACE) insulin pump and a separate 510(k) application for its SmartGuard™ algorithm as an interoperable automated glycemic controller (iAGC).

"We understand how meaningful these advancements are, and we're working with urgency to bring enhanced CGM options to our customers," said Que Dallara, EVP & president, Medtronic Diabetes. "This collaboration with Abbott marks an important step forward in providing innovative solutions and more choice for our customers."

This milestone follows the announcement last August that the companies will collaborate on an integrated system based on Abbott's most advanced CGM platform. Abbott will supply Medtronic with a CGM that will work exclusively with Medtronic smart dosing devices and software across both automated insulin delivery and smart multiple daily injections systems. These systems, including the Abbott CGM, will be sold exclusively by Medtronic.

More details will be shared when FDA clearance is secured.

About the Diabetes Business at Medtronic ( www.medtronicdiabetes.com )
Medtronic Diabetes is on a mission to alleviate the burden of diabetes by empowering individuals to live life on their terms, with the most advanced diabetes technology and always-on support when and how they need it. We've pioneered first-of-its-kind innovations for over 40 years and are committed to designing the future of diabetes management through next-generation sensors (CGM), intelligent dosing systems, and the power of data science and AI while always putting the customer experience at the forefront.

About Medtronic
Bold thinking. Bolder actions. We are Medtronic. Medtronic plc, headquartered in Galway , Ireland , is the leading global healthcare technology company that boldly attacks the most challenging health problems facing humanity by searching out and finding solutions. Our Mission — to alleviate pain, restore health, and extend life — unites a global team of 95,000+ passionate people across more than 150 countries. Our technologies and therapies treat 70 health conditions and include cardiac devices, surgical robotics, insulin pumps, surgical tools, patient monitoring systems, and more. Powered by our diverse knowledge, insatiable curiosity, and desire to help all those who need it, we deliver innovative technologies that transform the lives of two people every second, every hour, every day. Expect more from us as we empower insight-driven care, experiences that put people first, and better outcomes for our world. In everything we do, we are engineering the extraordinary. For more information on Medtronic (NYSE: MDT), visit www.Medtronic.com and follow Medtronic on LinkedIn .

Any forward-looking statements, including, but not limited to, statements regarding the partnership between Medtronic and Abbott, strategic and other potential benefits of the partnership, Abbott's products and product candidates, and other statements about Medtronic managements' future expectations, beliefs, goals, plans or prospects, are subject to risks and uncertainties including, but not limited to, the ability to obtain regulatory approvals, and other risks and uncertainties such as those described in Medtronic's reports and other filings with the Securities and Exchange Commission. Actual results may differ materially from anticipated results. Medtronic cautions investors not to place considerable reliance on the forward-looking statements contained in this press release. These forward-looking statements speak only as of the date of this document, and Medtronic undertakes no obligation to update or revise any of these statements except to the extent required by law.

Contacts:
Janet Cho
Public Relations
+1-818-403-7028

Ryan Weispfenning
Investor Relations
+1-763-505-4626

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SOURCE Medtronic plc

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Orchestra BioMed Announces AVIM Therapy-Focused Satellite Symposium at HRS 2025 Annual Meeting

Orchestra BioMed Announces AVIM Therapy-Focused Satellite Symposium at HRS 2025 Annual Meeting

  • FDA recently granted Breakthrough Device Designation to AVIM therapy for use in patients with uncontrolled hypertension at increased cardiovascular risk
  • HRS Satellite Symposium will feature leading experts in electrophysiology, hypertension management and heart failure
  • Presentations will detail clinical results from prior studies demonstrating AVIM therapy's ability to immediately, substantially and persistently reduce systolic blood pressure, as well as improve cardiac function
  • Symposium will also feature presentation on the BACKBEAT global pivotal study Orchestra BioMed is currently enrolling in strategic collaboration with Medtronic, plc (NYSE: MDT)

Orchestra BioMed Holdings, Inc. (Nasdaq: OBIO, "Orchestra BioMed" or the "Company"), a biomedical company accelerating high-impact technologies to patients through risk-reward sharing partnerships, today announced it will host an industry-sponsored satellite symposium at the Heart Rhythm Society ("HRS") 2025 Annual Meeting, taking place April 24–27, 2025, in San Diego, California featuring recent advancements in the Company's atrioventricular interval modulation ("AVIM") therapy program. The April 25 th 6:45 am PT symposium titled " The Future of Cardiac Pacing: Unlocking the Potential of Atrioventricular Interval Modulation (AVIM) Therapy " will convene leading electrophysiologists, hypertension and heart failure specialists to discuss the unmet need in hypertension, AVIM therapy mechanism of action, and growing body of clinical evidence supporting this novel therapy for the treatment of patients with uncontrolled hypertension who have increased cardiovascular risk with or without an indication for a pacemaker.

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Orchestra BioMed Receives FDA Breakthrough Device Designation for AVIM Therapy

Orchestra BioMed Receives FDA Breakthrough Device Designation for AVIM Therapy

  • Breakthrough Device Designation ("BDD") applies to an estimated U.S. population of over 7.7 million patients with uncontrolled hypertension and increased cardiovascular risk
  • BDD also encompasses pacemaker-indicated patients with uncontrolled hypertension who are the focus of the BACKBEAT global pivotal study Orchestra BioMed is currently enrolling in strategic collaboration with Medtronic, plc (NYSE: MDT)
  • BDD status provides accelerated FDA engagement and reviews for AVIM therapy; it also supports potential pathways to secure higher reimbursement for AVIM-enabled devices in the future

Orchestra BioMed Holdings, Inc. (Nasdaq: OBIO) ("Orchestra BioMed" or the "Company"), a biomedical company accelerating high-impact technologies to patients through risk-reward sharing partnerships, today announced that the U.S. Food and Drug Administration ("FDA") has granted Breakthrough Device Designation ("BDD") for atrioventricular interval modulation ("AVIM") therapy.

Specifically, the BDD is for an implantable system (i.e., a pacemaker) to deliver AVIM therapy using conduction system pacing to reduce blood pressure in patients with increased ten-year atherosclerotic cardiovascular disease ("ASCVD") risk, preserved left ventricular systolic function, and uncontrolled hypertension, despite the use of anti-hypertensive medications or in patients who may have intolerance to anti-hypertensive medications. Orchestra BioMed estimates that there are over 7.7 million patients in the U.S. that meet the criteria for the BDD for AVIM therapy. AVIM therapy is currently being evaluated under an FDA investigational device exemption ("IDE") in the BACKBEAT global pivotal study which is being conducted by Orchestra BioMed in collaboration with Medtronic. The BACKBEAT pivotal study is enrolling pacemaker-indicated patients with uncontrolled hypertension despite the use of anti-hypertensive medication, a key subpopulation under the BDD for which Orchestra BioMed believes AVIM therapy may offer optimal clinical benefit.

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Medtronic Evolut TAVR system shows durable clinical outcomes and outstanding valve performance at five years in low-risk aortic stenosis patients

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The Evolut Low Risk Trial was a randomized, multicenter, international study assessing the safety and efficacy of the Evolut TAVR system versus surgery in low-risk patients. These patients had a predicted 30-day mortality risk

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