Ginkgo Bioworks Reports Third Quarter 2022 Financial Results

Ginkgo Bioworks Reports Third Quarter 2022 Financial Results

15 new Cell Programs added and $66 million of Total revenue in Q3 2022

Closed four acquisitions in October, including Zymergen and Bayer's West Sacramento agricultural biologicals capabilities, enabling commencement of integration and pursuit of new growth opportunities

End of quarter cash balance of over $1.3 billion provides continued financial flexibility

Ginkgo Bioworks Holdings, Inc. (NYSE: DNA, "Ginkgo"), which is building the leading platform for cell programming and biosecurity, today announced its results for the third quarter ended September 30, 2022 . The update, including a webcast slide presentation with additional details on the third quarter and supplemental financial information, will be available at investors.ginkgobioworks.com .

(PRNewsfoto/Ginkgo Bioworks)

"I'm very excited about the strategic progress we have made at Ginkgo, highlighted by the four acquisitions we completed in October, and I'm thrilled to welcome our new team members. I believe these additions will meaningfully strengthen our platform and services," said Jason Kelly , co-founder and CEO of Ginkgo. "Our team worked extremely hard to close both the Zymergen and Bayer transactions efficiently, with the Zymergen transaction in particular closing well in advance of our initial expectations. The faster Zymergen closing timeline provides us with significant strategic benefits, including a higher acquired cash balance and the ability to immediately focus Zymergen's outstanding team and assets on Ginkgo's core service offering. Successful M&A execution illustrates our ability to take advantage of opportunities catalyzed by the current market environment, while our strong standalone cash balance of over $1.3 billion at the end of the third quarter continues to afford us substantial flexibility."

Recent Business Highlights & Strategic Positioning

  • Generated Foundry revenue of $25 million in Q3 2022
  • Added 15 new Cell Programs to the Foundry platform in Q3 2022, representing 50% growth over the comparable prior year period
    • Continued traction in pharma and biotech, including a collaboration with Merck to engineer enzymes for use as biocatalysts in Merck's active pharmaceutical ingredient (API) manufacturing efforts
  • Concentric by Ginkgo, Ginkgo's biosecurity and public health offering, executed well in Q3 2022, generating $42 million in Biosecurity revenue
    • Expanded internationally, including Memoranda of Understanding with the Rwanda Development Board and the Ministry of Investment of Saudi Arabia
    • Added enhanced analytic modules, including epidemiological tracking, modeling, and forecasting capabilities, and announced computational tools to detect engineered biology in collaboration with the Intelligence Advanced Research Projects Activity (IARPA)
    • Continuing to pilot new modalities and offerings, including passive monitoring of wastewater and air
  • Completed acquisitions of Zymergen and Bayer's West Sacramento Biologics Research & Development site in October
    • The swift closing of the Zymergen transaction delivers more cash at close and enables Ginkgo to commence integration activities and pursue new growth opportunities faster than originally anticipated
  • Also in October, acquired Altar, which has developed a robust adaptive laboratory evolution (ALE) platform, and Circularis, a proprietary circular RNA and promoter screening platform

Third Quarter 2022 Financial Highlights

  • Third quarter 2022 Total revenue of $66 million , down from $78 million in the comparable prior year period, a decrease of 14%
    • Third quarter 2022 Foundry revenue of $25 million , down from $35 million in the comparable prior year period, a decrease of 29%. Third quarter 2022 Foundry revenue did not include any large milestone payments, while the third quarter 2021 Foundry revenue included downstream value share revenue related to an equity milestone achievement by Cronos Group Inc.
    • Third quarter 2022 Biosecurity revenue of $42 million , down from $43 million in the comparable prior year period, a decrease of 3%. Third quarter 2022 Biosecurity gross profit margin of 41%
  • Third quarter 2022 Loss from operations of $(653) million (inclusive of stock-based compensation expense of $563 million ), compared to Loss from operations of $(27) million in the comparable prior year period. The stock-based compensation expense primarily relates to the continued GAAP accounting for the modification of restricted stock units issued prior to becoming a public company, as disclosed in our annual report on Form 10-K filed with the SEC on March 29, 2022
  • Third quarter 2022 Adjusted EBITDA of $(70) million , down from $(18) million in the comparable prior year period
  • Cash and cash equivalents balance as of the end of the third quarter of over $1.3 billion puts Ginkgo in a strong financial position to pursue its strategic objectives

Full Year 2022 Guidance

  • Ginkgo expects to add 55-60 new Cell Programs to the Foundry platform in 2022
  • Ginkgo further revised its expectation for Total revenue from $425 $440 million to $460 $480 million in 2022
  • Ginkgo revised its expectation for Foundry revenue to $150 $170 million in 2022, which reflects our current assumptions and uncertainty regarding the timing of certain discrete milestone payments
  • While Biosecurity remains an uncertain business, based on strong year-to-date performance Ginkgo now expects Biosecurity revenue in 2022 of at least $310 million

Conference Call Details

Ginkgo will host a videoconference today, Monday, November 14, 2022 , beginning at 4:30 p.m. ET . The presentation will include an overview of the third quarter financial performance, recent business updates, a discussion on Ginkgo's outlook, as well as a moderated question and answer session.

To ask a question ahead of the presentation, please submit your questions to @Ginkgo on Twitter (hashtag #GinkgoResults) or by sending an e-mail to investors@ginkgobioworks.com .

A webcast link is available on Ginkgo's Investor Relations website and a replay will be made available following the presentation.

Ginkgo Investor Website: https://investors.ginkgobioworks.com/events/

Audio-Only Dial Ins:  
+1 646 876 9923 ( New York )
+1 301 715 8592 ( Washington DC )
+1 312 626 6799 ( Chicago )
+1 669 900 6833 ( San Jose )
+1 253 215 8782 (Tacoma)
+1 346 248 7799 ( Houston )
+1 408 638 0968 ( San Jose )

Webinar ID: 936 0665 8370

If you experience technical difficulties with any of these dial-ins or if you need international dial-in numbers, please visit our web site at https://investors.ginkgobioworks.com/events/ for updated dial-in information.

About Ginkgo Bioworks

Ginkgo Bioworks is the leading horizontal platform for cell programming, providing flexible, end-to-end services that solve challenges for organizations across diverse markets, from food and agriculture to pharmaceuticals to industrial and specialty chemicals. Ginkgo's biosecurity and public health unit, Concentric by Ginkgo, is building global infrastructure for biosecurity to empower governments, communities, and public health leaders to prevent, detect and respond to a wide variety of biological threats. For more information, visit ginkgobioworks.com and concentricbyginkgo.com , read our blog , or follow us on social media channels such as Twitter (@ Ginkgo and @ ConcentricByGBW ), Instagram (@ GinkgoBioworks and @ ConcentricByGinkgo ), or LinkedIn .

Forward-Looking Statements of Ginkgo Bioworks

This press release, the presentation, and the conference call and webcast contain certain forward-looking statements within the meaning of the federal securities laws, including statements regarding our plans, strategies, current expectations, operations and anticipated results of operations, both business and financial, all of which are subject to known and unknown risks, uncertainties and other factors that may cause our actual results, performance or achievements, market trends, or industry results to differ materially from those expressed or implied by such forward-looking statements. These forward-looking statements generally are identified by the words "believe," "can," "project," "potential," "expect," "anticipate," "estimate," "intend," "strategy," "future," "opportunity," "plan," "may," "should," "will," "would," "will be," "will continue," "will likely result," and similar expressions. Forward-looking statements are predictions, projections and other statements about future events that are based on current expectations and assumptions and, as a result, are subject to risks and uncertainties. Many factors could cause actual future events to differ materially from the forward-looking statements in this document, including but not limited to: (i) volatility in the price of Ginkgo's securities due to a variety of factors, including changes in the competitive and highly regulated industries in which Ginkgo operates and plans to operate, variations in performance across competitors, and changes in laws and regulations affecting Ginkgo's business, (ii) the ability to implement business plans, forecasts, and other expectations, and to identify and realize additional business opportunities, (iii) the risk of downturns in demand for products using synthetic biology, (iv) the unpredictability of the duration of the COVID-19 pandemic and the demand for COVID-19 testing and the commercial viability of our COVID-19 testing business, (v) changes to the biosecurity industry, including due to advancements in technology, emerging competition and evolution in industry demands, standards and regulations, and (vi) our ability to realize the expected benefits of merger and acquisition transactions. The foregoing list of factors is not exhaustive. You should carefully consider the foregoing factors and the other risks and uncertainties described in the "Risk Factors" section of Ginkgo's most recent quarterly report on Form 10-Q filed with the U.S. Securities and Exchange Commission (the "SEC"), and other documents filed by Ginkgo from time to time with the SEC. These filings identify and address other important risks and uncertainties that could cause actual events and results to differ materially from those contained in the forward-looking statements. Forward-looking statements speak only as of the date they are made. Readers are cautioned not to put undue reliance on forward-looking statements, and Ginkgo assumes no obligation and does not intend to update or revise these forward-looking statements, whether as a result of new information, future events, or otherwise. Ginkgo does not give any assurance that it will achieve its expectations.

Use of Non-GAAP Financial Measures

Certain of the financial measures included in this release, including Adjusted EBITDA, have not been prepared in accordance with generally accepted accounting principles ("GAAP"), and constitute "non-GAAP financial measures" as defined by the SEC.  Ginkgo has included these non-GAAP financial measures because it believes they provide an additional tool for investors to use in evaluating Ginkgo's financial performance and prospects. Due to the nature and/or size of the items being excluded, such items do not reflect future gains, losses, expenses or benefits and are not indicative of our future operating performance. These non-GAAP financial measures are supplemental to, should not be considered in isolation from, or as an alternative to, financial measures determined in accordance with GAAP. In addition, these non-GAAP financial measures may differ from non-GAAP financial measures with comparable names used by other companies. See the reconciliation below for additional information regarding certain of the non-GAAP financial measures included in this release, including a description of these non-GAAP financial measures and a reconciliation of the historic measures to Ginkgo's most comparable GAAP financial measures.

Ginkgo Bioworks Contacts:

INVESTOR CONTACT:
  investors@ginkgobioworks.com

MEDIA CONTACT:
  press@ginkgobioworks.com

Ginkgo Bioworks Holdings, Inc.

Condensed Consolidated Balance Sheets

(in thousands, except per share data, unaudited)








As of September 30,


As of December 31,



2022


2021

Assets





Current assets:





Cash and cash equivalents


$1,302,603


$1,550,004

Accounts receivable, net


113,661


131,544

Accounts receivable - related parties


2,095


4,598

Inventory, net


5,860


3,362

Prepaid expenses and other current assets


37,784


33,537

Total current assets


1,462,003


1,723,045

Property and equipment, net


187,577


145,770

Investments


96,310


102,037

Equity method investments


4,135


13,194

Intangible assets, net


47,938


21,642

Goodwill


28,804


21,312

Other non-current assets


43,928


43,990

Total assets


$1,870,695


$2,070,990

Liabilities and Stockholders' Equity





Current liabilities:





Accounts payable


$ 11,323


$ 8,189

Deferred revenue


40,505


33,240

Accrued expenses and other current liabilities


72,990


93,332

Total current liabilities


124,818


134,761

Non-current liabilities:





Deferred rent, net of current portion


21,001


18,746

Deferred revenue, net of current portion


150,637


155,991

Lease financing obligation


59,842


22,283

Warrant liabilities


39,739


135,838

Other non-current liabilities


34,922


35,992

Total liabilities


430,959


503,611

Commitments and contingencies





Stockholders' equity:





Preferred stock, $0.0001 par value



Common stock, $0.0001 par value


165


161

Additional paid-in capital


5,668,791


3,804,844

Accumulated deficit


(4,226,310)


(2,297,925)

Accumulated other comprehensive loss


(7,910)


(1,715)

Total Ginkgo Bioworks Holdings, Inc. stockholders' equity


1,434,736


1,505,365

Non-controlling interest


5,000


62,014

Total stockholders' equity


1,439,736


1,567,379

Total liabilities and stockholders' equity


$1,870,695


$2,070,990

Ginkgo Bioworks Holdings, Inc.

Condensed Consolidated Statements of Operations and Comprehensive Loss

(in thousands, except share and per share data, unaudited)




Three Months Ended September 30,


Nine Months Ended September 30,



2022


2021


2022


2021

Foundry revenue


$24,679


$34,737


$90,409


$78,833

Biosecurity revenue:









Product


5,190


8,492


23,024


14,622

Service


36,529


34,381


265,988


71,888

Total revenue


66,398


77,610


379,421


165,343

Costs and operating expenses:









Cost of Biosecurity product revenue


2,660


3,430


13,199


15,185

Cost of Biosecurity service revenue


21,995


18,872


160,799


47,927

Research and development (1)


259,580


53,021


871,488


164,637

General and administrative (1)


435,184


28,959


1,308,379


81,326

Total operating expenses


719,419


104,282


2,353,865


309,075

Loss from operations


(653,021)


(26,672)


(1,974,444)


(143,732)

Other (expense) income:









Interest income (expense), net


5,820


(528)


7,097


(1,481)

Loss on equity method investments


(22,711)


(39,651)


(53,764)


(72,621)

(Loss) gain on investments


(1,758)


(12,368)


(39,981)


3,009

Change in fair value of warrant liabilities


(12,445)


(18,482)


96,099


(18,482)

Gain on deconsolidation of subsidiaries


15,989



31,889


Other (expense) income, net


(957)


(4,911)


629


863

Total other (expense) income, net


(16,062)


(75,940)


41,969


(88,712)

Loss before income taxes


(669,083)


(102,612)


(1,932,475)


(232,444)

Income tax benefit


(28)


(207)


(257)


(797)

Net loss


(669,055)


(102,405)


(1,932,218)


(231,647)

Net loss attributable to non-controlling interest



(524)


(3,833)


(2,256)

Net loss attributable to Ginkgo Bioworks Holdings, Inc. stockholders


$(669,055)


$(101,881)


$ (1,928,385)


$(229,391)

Net loss per share attributable to Ginkgo Bioworks Holdings, Inc. common stockholders, basic and diluted


$(0.41)


$(0.08)


$(1.19)


$(0.18)

Weighted average common shares outstanding, basic and diluted


1,630,910,628


1,323,574,063


1,619,790,335


1,302,253,729

Comprehensive loss:









Net loss


$(669,055)


$(102,405)


$ (1,932,218)


$(231,647)

Other comprehensive loss:









Foreign currency translation adjustment


(2,414)


(877)


(6,195)


(877)

Total other comprehensive loss


(2,414)


(877)


(6,195)


(877)

Comprehensive loss


$(671,469)


$(103,282)


$ (1,938,413)


$(232,524)


1)     In the three and nine months ended September 30, 2022, R&D and G&A expenses included a significant charge to stock-based compensation expense as a result of the modification of
the vesting terms of restricted stock units and all related earnout shares. Total stock-based compensation expense, inclusive of $0.2 million and $7.2 million in employer payroll taxes for
the three and nine months ended September 30, 2022, respectively, was as follows:





Three Months Ended September 30,


Nine Months Ended September 30,

(in thousands)


2022


2021


2022


2021

Research and development


$187,019


$20


$ 670,650


$60

General and administrative


376,366


107


1,159,040


14,704

Total


$563,385


$ 127


$ 1,829,690


$14,764

Ginkgo Bioworks Holdings, Inc.

Condensed Consolidated Statements of Cash Flows

(in thousands, unaudited)








Nine Months Ended September 30,



2022


2021

Cash flows from operating activities:





Net loss


$ (1,932,218)


$(231,647)

Adjustments to reconcile net loss to net cash used in operating activities:





Depreciation and amortization


28,602


21,073

Stock-based compensation


1,822,472


14,764

Loss on equity method investments


53,764


72,621

Loss (gain) on investments


39,981


(3,009)

Non-cash customer consideration


(18,139)


(12,562)

Change in fair value of notes receivable


(269)


1,196

Change in fair value of warrant liabilities


(96,099)


18,482

Gain on deconsolidation of subsidiaries


(31,889)


In-process research and development


1,162


Loss on disposal of equipment


3,091


Other non-cash activity


303


Changes in operating assets and liabilities:





Accounts receivable


20,521


(28,670)

Prepaid expenses and other current assets


8,347


5,565

Inventory


(2,498)


(738)

Other non-current assets


144


(35)

Accounts payable


3,893


(2,771)

Accrued expenses and other current liabilities


(15,637)


29,599

Deferred revenue, current and non-current


(35,365)


(5,538)

Deferred rent, non-current


2,255


4,320

Other non-current liabilities


82


29,073

Net cash used in operating activities


(147,497)


(88,277)

Cash flows from investing activities:





Purchase of convertible note


(10,000)


Purchases of property and equipment


(26,626)


(51,407)

Purchase of investment in equity securities


(3,691)


(5,000)

Deconsolidation of subsidiaries - cash


(55,721)


Business and asset acquisitions, net of cash acquired


(657)


(21,382)

Other


(439)


304

Net cash used in investing activities


(97,134)


(77,485)

Cash flows from financing activities:





Proceeds from reverse recapitalization, net of redemptions of $867,253 and offering costs of $106,838



1,510,909

Proceeds from exercise of stock options


120


41

Taxes paid related to net share settlement of equity awards


(981)


Repurchase of Founder shares



(24,998)

Principal payments on capital leases and lease financing obligation


(1,082)


(764)

Non-controlling interest contributions



60,000

Contingent consideration payment


(521)


Payment of equity offering issuance costs


(132)


Net cash (used in) provided by financing activities


(2,596)


1,545,188

Effect of foreign exchange rates on cash and cash equivalents


(191)


(8)

Net (decrease) increase in cash, cash equivalents and restricted cash


(247,418)


1,379,418






Cash and cash equivalents, beginning of period


1,550,004


380,801

Restricted cash, beginning of period


42,924


5,076

Cash, cash equivalents and restricted cash, beginning of period


1,592,928


385,877






Cash and cash equivalents, end of period


1,302,603


1,739,056

Restricted cash, end of period


42,907


26,239

Cash, cash equivalents and restricted cash, end of period


$1,345,510


$1,765,295






Ginkgo Bioworks Holdings, Inc.

Selected Non-GAAP Financial Measures

(in thousands, unaudited)












Three Months Ended September 30,


Nine Months Ended September 30,



2022


2021


2022


2021

Net loss attributable to Ginkgo Bioworks Holdings, Inc. stockholders


$ (669,055)


$ (101,881)


$(1,928,385)


$ (229,391)

Interest (income) expense, net


(5,820)


528


(7,097)


1,481

Income tax benefit


(28)


(207)


(257)


(797)

Depreciation and amortization


9,506


8,279


28,602


21,073

EBITDA


(665,397)


(93,281)


(1,907,137)


(207,634)

Stock-based compensation (1)


563,385


127


1,829,690


14,764

Loss on equity method investments (2)


22,711


39,127


52,927


70,365

Loss (gain) on investments


1,758


12,368


39,981


(3,009)

Change in fair value of warrant liabilities


12,445


18,482


(96,099)


18,482

Gain on deconsolidation of subsidiaries


(15,989)



(31,889)


Merger and acquisition related expenses (3)


12,017



18,579


In-process research and development (4)




1,605


Other (5)


(561)


5,192


(229)


421

Adjusted EBITDA


$ (69,631)


$ (17,985)


$ (92,572)


$ (106,611)




(1) For the three and nine months ended September 30, 2022, includes employer payroll taxes of $0.2 million and $7.2 million, respectively.

(2) Represents losses on equity method investments under the hypothetical liquidation at book value method, net of losses attributable to
non-controlling interests.

(3) Represents transaction and integration costs directly related to mergers and acquisitions including (i) due diligence, legal and other
professional fees associated with acquisitions and (ii) the fair value adjustments to contingent consideration liabilities resulting from
acquisitions.

(4) Represents acquired intangible assets expensed to research and development associated with an asset acquisition.

(5) For the three and nine months ended September 30, 2022, includes changes in fair value of the Access Bio Convertible Notes and the
Glycosyn Promissory Note. For the three and nine months ended September 30, 2021, includes changes in fair value of the Access Bio
Convertible Notes and the Glycosyn Promissory Note as well as gain related to a settlement payment.

Ginkgo Bioworks Holdings, Inc.

Segment Information

(in thousands, unaudited)










Three Months Ended September 30,


Nine Months Ended September 30,


2022


2021


2022


2021

Revenue:








Foundry

$24,679


$34,737


$90,409


$78,833

Biosecurity

41,719


42,873


289,012


86,510

Total revenue

66,398


77,610


379,421


165,343

Segment cost of revenue:








Biosecurity

24,655


22,302


173,998


63,112

Segment research and development expense:








Foundry

63,402


42,897


173,470


114,619

Biosecurity

387


2,093


1,347


29,870

Total segment research and development expense

63,789


44,990


174,817


144,489

Segment general and administrative expense:








Foundry

41,569


17,026


104,863


44,903

Biosecurity

17,039


11,689


42,683


21,308

Total segment general and administrative expense

58,608


28,715


147,546


66,211

Segment operating income (loss):








Foundry

(80,292)


(25,186)


(187,924)


(80,689)

Biosecurity

(362)


6,789


70,984


(27,780)

Total segment operating income (loss)

(80,654)


(18,397)


(116,940)


(108,469)

Operating expenses not allocated to segments:








Stock-based compensation (1)

563,385


127


1,829,690


14,764

Depreciation and amortization

9,224


8,148


27,756


20,499

Change in fair value of contingent consideration liability

(242)



58


Loss from operations

$(653,021)


$(26,672)


$ (1,974,444)


$(143,732)









(1) Includes $0.2 million and $7.2 million in employer payroll taxes for the three and nine months ended September 30, 2022, respectively.

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SOURCE Ginkgo Bioworks

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Illumina Inc. (NASDAQ: ILMN), a global leader in DNA sequencing and array-based technologies, announced that it has completed integration of its latest chemistry, XLEAP-SBS ™ into all reagents for its NextSeq ™ 1000 and NextSeq 2000 next-generation sequencing (NGS) instruments.

"We are excited to deliver for our NextSeq 1000/2000 customers improved sequencing with faster run times, better quality, and higher output—all at lower cost per kit," said Jason Johnson , head of Global Product Management at Illumina. "XLEAP-SBS chemistry on NextSeq 1000/2000 will enable labs to perform bigger NGS projects without raising the budget, and facilitate greater adoption of multiomic approaches."

In March, the company launched its P4 flow cell (highest output of 540 Gb) with XLEAP-SBS chemistry for the NextSeq 2000, and today it announced that the XLEAP-SBS P1, P2, and P3 flow cells are all now available. XLEAP-SBS chemistry is a faster, higher quality, and more robust sequencing-by-synthesis chemistry that delivers approximately 20% faster turnaround times.

Early-access customers have shared positive feedback on improved quality, stability, and run times. Marc Monot , PhD, head of Biomics at the Institut Pasteur, said, "We were very happy with the quantity and quality of the reads. The Q is very close to Q40 and the stability is a game changer for Illumina. From the first base to the last base, [Illumina] improved the quality of the run quite a lot."

The NextSeq 1000 and NextSeq 2000 Systems are flexible and scalable mid-throughout sequencers that enable a range of applications, including single-cell, whole-exome, and RNA sequencing.

Use of forward-looking statements

This release contains forward-looking statements that involve risks and uncertainties, including the expectation for lower costs related to the storing and managing of genomic data costs. Among the important factors that could cause actual results to differ materially from those in any forward-looking statements are: (i) challenges inherent in developing and launching new products and services, including meeting manufacturing, quality, and performance requirements; (ii) our ability to deploy new products, services, and applications, and to expand the markets for our technology platforms; and (iii) the acceptance by customers of our newly launched products, which may or may not meet our and their expectations once deployed, together with other factors detailed in our filings with the Securities and Exchange Commission, including our most recent filings on Forms 10-K and 10-Q, or in information disclosed in public conference calls, the date and time of which are released beforehand. We undertake no obligation, and do not intend, to update these forward-looking statements, to review or confirm analysts' expectations, or to provide interim reports or updates on the progress of the current quarter.

About Illumina

Illumina is improving human health by unlocking the power of the genome. Our focus on innovation has established us as a global leader in DNA sequencing and array-based technologies, serving customers in the research, clinical, and applied markets. Our products are used for applications in the life sciences, oncology, reproductive health, agriculture, and other emerging segments. To learn more, visit illumina.com and connect with us on X , Facebook , LinkedIn , Instagram , TikTok , and YouTube

Contacts

Investors:  
Salli Schwartz
858-291-6421
IR@illumina.com

Media:  
Samantha Beal
PR@illumina.com

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SOURCE Illumina, Inc.

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