Arch Biopartners Announces Positive Results of Dose Escalation Human Trial for LSALT Peptide

Arch Biopartners Announces Positive Results of Dose Escalation Human Trial for LSALT Peptide

Today, ARCH Biopartners Inc., ("ARCH" or the "Company") (TSX Venture: ARCH and OTCQB: ACHFF), a clinical stage company focused on the development of novel therapeutics targeting organ inflammation, announced that it has safely increased the maximum daily dose of LSALT peptide to 20 mg per day in healthy, normal volunteers in a recently completed human trial in Australia.

LSALT peptide is the Company's lead drug candidate for treating inflammation in the lungs, liver and kidneys and Arch intends to use the new maximum dose in designing a Phase II trial targeting cardiac surgery-associated acute kidney injury (CS-AKI). The new safety data will be included in an Investigational New Drug Application to the U.S. FDA, to be submitted in relation to the CS-AKI trial in due course.

Prior to this dose escalation trial, LSALT peptide was administered at a maximum of 5mg once daily, for up to 14 days, in hospitalized COVID-19 patients during a Phase II trial targeting inflammation in the lungs.

Dose Escalation Trial

The dose escalation human trial was performed at the Alfred Hospital in Melbourne, Australia. The trial was a double-blind, placebo-controlled, randomized, single and multiple ascending dose study to evaluate the safety and pharmacokinetic profile of LSALT peptide. Sixteen healthy, normal volunteers participated, receiving either LSALT peptide or a placebo, and were divided into two groups.

Six participants in each group received a daily dosing of LSALT peptide for one day followed by three consecutive days of dosing. Two people per group received a placebo with the same dosing schedule. In the first group, six people received a once daily, 10 mg intravenous (IV) dose of LSALT peptide. In the second group, six volunteers received a 10 mg IV dose of LSALT peptide twice a day, approximately every 12 hours.

In both groups, LSALT peptide met the primary endpoints of safety and tolerability.

LSALT Peptide Drug Product Manufacturing Update

During the last few months, Arch has continued to advance the production of new supply of LSALT peptide to be used in non-Covid human trials. The production of approximately 10,000 LSALT peptide drug product vials has recently been completed. The new vials are undergoing quality control and quality assurance procedures at the Company's third-party manufacturing facility in Toronto, Canada. The drug product vials contain approximately 5mg of LSALT peptide and are expected to be released to Arch in May 2023.

About Arch Biopartners

Arch Biopartners Inc. is a clinical stage company focused on the development of innovative technologies that have the potential to make a significant medical or commercial impact. Arch Biopartners is developing a pipeline of new drug candidates that inhibit inflammation in the lungs, kidneys and liver via the dipeptidase-1 (DPEP-1) pathway, relevant for multiple medical indications.

For more information on Arch Biopartner's science and technologies, please visit:

For investor information and other public documents the company has also filed on SEDAR, please visit

The Company has 62,398,825 common shares outstanding.

Forward-Looking Statements

This press release contains forward-looking statements within the meaning of applicable Canadian securities laws regarding expectations of our future performance, liquidity and capital resources, as well as the ongoing clinical development of our drug candidates targeting the dipeptidase-1 (DPEP-1) pathway, including the outcome of our clinical trials relating to LSALT Peptide (Metablok), the successful commercialization and marketing of our drug candidates, whether we will receive, and the timing and costs of obtaining, regulatory approvals in Canada, the United States, Europe and other countries, our ability to raise capital to fund our business plans, the efficacy of our drug candidates compared to the drug candidates developed by our competitors, our ability to retain and attract key management personnel, and the breadth of, and our ability to protect, our intellectual property portfolio. These statements are based on management's current expectations and beliefs, including certain factors and assumptions, as described in our most recent annual audited financial statements and related management discussion and analysis under the heading "Business Risks and Uncertainties". As a result of these risks and uncertainties, or other unknown risks and uncertainties, our actual results may differ materially from those contained in any forward-looking statements. The words "believe", "may", "plan", "will", "estimate", "continue", "anticipate", "intend", "expect" and similar expressions are intended to identify forward-looking statements, although not all forward-looking statements contain these identifying words. We undertake no obligation to update forward-looking statements, except as required by law. Additional information relating to Arch Biopartners Inc., including our most recent annual audited financial statements, is available by accessing the Canadian Securities Administrators' System for Electronic Document Analysis and Retrieval ("SEDAR") website at .

The science and medical contents of this release have been approved by the Company's Chief Science Officer.

Neither TSX Venture Exchange nor its Regulation Services Provider (as that term is defined in the policies of the TSX Venture Exchange) accepts responsibility for the adequacy or accuracy of this release .

For more information, please contact: Richard Muruve Chief Executive Officer Arch Biopartners, Inc. 647-428-7031 

Primary Logo

News Provided by GlobeNewswire via QuoteMedia

The Conversation (0)
Precigen Announces Groundbreaking Pivotal Study Data for PRGN-2012 in Patients with Recurrent Respiratory Papillomatosis in Which More than Half of Patients Achieved Complete Response

Precigen Announces Groundbreaking Pivotal Study Data for PRGN-2012 in Patients with Recurrent Respiratory Papillomatosis in Which More than Half of Patients Achieved Complete Response

Phase 12 pivotal study met the primary safety and efficacy endpoints –

51% (18 out of 35) of patients achieved Complete Response, requiring no surgeries after treatment with PRGN-2012; complete responses have been durable beyond 12 months with median duration of follow up of 20 months as of data cutoff –

News Provided by PR Newswire via QuoteMedia

Keep reading...Show less
RUA GOLD Provides an Update on the Reefton Drilling Program and the next phase of drill targets

RUA GOLD Provides an Update on the Reefton Drilling Program and the next phase of drill targets

RUA GOLD Corporation (CSE: RUA) (OTC: NZAUF) (WKN: A4010V) ("RUA GOLD" or the "Company") is pleased to provide an exploration update for the Reefton Project on the South Island of New Zealand .

  • Preliminary results confirm the Pactolus system extends south for 550 meters along strike and is well mineralized on surface.
  • The Company is analyzing the results to better understand the plunge and tenor of the ore shoots at this early stage of exploration.
  • The Company has developed multiple new high-grade targets at past producing mines in the Murray Creek area for drill testing in Q2/2024.


News Provided by Canada Newswire via QuoteMedia

Keep reading...Show less
Nickel Creek Platinum Announces Positive PFS for its Nickel Shäw Project

Nickel Creek Platinum Announces Positive PFS for its Nickel Shäw Project

 Nickel Creek Platinum Corp. (TSX: NCP) (OTCQB: NCPCF) ("Nickel Creek" or the "Company") is pleased to announce the results of a positive pre-feasibility study ("PFS") at its 100%-owned Nickel Shäw Project (the "Project") located in the Yukon Canada. The PFS has been prepared by AGP Consultants Inc. ("AGP"). The estimated Project after-tax net present value ("NPV") at a 5% discount rate is $143 million with an after-tax internal rate of return ("IRR") of 5.8%. All dollars are expressed in Canadian dollars unless otherwise stated.

Nickel Creek Platinum Corp. logo (CNW Group/Nickel Creek Platinum Corp.)

Stuart Harshaw , President and CEO of Nickel Creek commented: "The PFS is an important milestone in realizing the opportunity the Nickel Shäw Project represents in the critical mineral space where it can provide nickel and copper to take advantage of the strong nickel market for EV batteries. The sensitivity to energy costs illustrates how working with the different levels of government can lead to a significant improvement in value, especially when combined with the previously announced intention of the Federal government to provide a tax incentive for critical mineral projects such as Nickel Shäw.  Moving forward, our focus will be to continue to add value to the project through work on identified key economic areas of opportunity and continued mineral exploration success while advancing towards a feasibility study."

Project PFS Highlights
  • $143 million after-tax NPV using a 5% discount rate and an IRR of 5.8% at the following commodity prices: nickel - US$11.00 /pound ("lb"); copper – US$4.00 /lb; palladium – US$2,100 /troy ounce ("troy oz"); platinum – US$1,000 /troy oz; cobalt – US$23 /lb; and gold – US$1,800 /troy oz, each using a 0.75 Canadian to US exchange rate.
  • Life of mine ("LOM") after-tax cash flow of approximately $1.7 billion with an after-tax payback period of 12.7 years.
  • Pre-production capital cost of approximately $1.7 billion , with a construction period of 3.0 years.
Project Opportunities
  • If paying Yukon grid rates of $0.11 /kWhr, the after-tax NPV at a 5% discount rate increases by $324 million to $467 million (see NPV sensitivities section below for additional information).
  • The Company's after-tax NPV at a 5% discount rate increases from $143 million to $336 million if the Canadian tax incentive for critical mineral companies is enacted (see Investment Tax Credit for Clean Technology Manufacturing section below for additional information).
  • The Company plans to further investigate the opportunity of carbon tax offsets associated with carbon sequestration in the tailings facility with ongoing testwork and analysis.
Mineral Resource

On June 1, 2023 , the Company announced an updated mineral resource estimate with an effective date of April 3, 2023 :

Metal Grades







































Total M+I




















Contained Metal









M Lbs

M Lbs

M Lbs

k Ozs

k Ozs

k Ozs

















Total M+I

















Mineral Resources that are not Mineral Reserves do not have demonstrated economic viability.

Summation errors may occur due to rounding.

Effective Date is April 3, 2023.

Mineral Resources amenable to open pit extraction are reported within an optimized containing shell.

Average grade calculations on this table are impacted by rounding.

Tonnages are reported in units of 1,000 metric tonnes (Ktonnes).

Contained Base Metal reported in units of 1,000,000 lbs, M Lbs.

Contained Precious Metal reported in units of 1,000 troy ounces, K Ozs.

Metal Prices for Resource Determination in US$

Nickel: $12.10/lb; Copper: $4.45/lb; Cobalt: $25.30/lb; Palladium: $2,415/troy oz; Platinum: $1,150/troy oz; Gold: $2,015/troy oz.

Net Smelter Return (NSR) cut-off grades range from $17.30 to $17.61 Canadian dollars depending on Bulk Con and Split Con

Mining costs, vary by bench, separately for ore and waste:

Base waste mining cost @1330m = C$2.26/t, 10 m bench incremental cost above = C$0.004/t, 10 m bench incremental cost below = C$0.02/t

Base ore mining cost @1330m = C$1.99/t, 10 m bench incremental cost above = C$0.019/t, 10 m bench incremental cost below = C$0.015/t

Process and G&A costs: Bulk con – C$17.30/t; Split con = C$17.61/t

Calculated process recoveries by concentrate type:







Bulk con:



57.0 %

54.0 %

47.8 %

74.4 %

Cu con:



3.36 %

3.19 %

0.91 %

23.58 %

Ni con:



53.64 %

50.81 %

46.89 %

50.82 %


Eq1 = Ni recovery to Bulk Con = MIN (23.21*LN(X)+30.362,88)


X = (%S-%Cu)/%Ni Capped at 12.0%

Eq2 = Cu recovery to Bulk Con = ((Cu-0.06)/Cu)) *100, Constant tail at 0.06% Cu

Eq3 = Ni recovery to Cu Con=Ni recovery to achieve 25.6% Cu and 1.1% Ni grades in Cu Con

Eq4 = Cu recovery to Cu Con = Cu recovery to Bulk Con * 0.623

Eq5 = Ni recovery to Bulk Con – Ni recovery to Cu Con

Eq6 = Cu recovery to Bulk Con – Cu recovery to Cu Con

Capping of grades varies based on lithology for each metal.

The density is assigned based on lithology and varies between 2.76 g/cm 3 and 3.38 g/cm 3 .

Project Description

The Company's flagship asset is its 100%-owned Nickel Shäw Ni-Cu-Co-PGM Project, located in southwestern Yukon, Canada . The Nickel Shäw Project contains the Company's core Ni-Cu-Co-PGM Wellgreen deposit, as well as the Arch, Burwash, Formula, Musk and Quill claims. The Wellgreen deposit is a polymetallic deposit with mineralization that includes the significant co-occurrence of nickel, copper, cobalt, platinum group metals ("PGMs") and gold.

The Nickel Shäw property contains an extensive Ni-Cu-Co-PGM mineralized system hosted by mafic/ultramafic intrusions related to Triassic-age flood basalts. With over 2.4 billion pounds of nickel, 1.2 billion pounds of copper, 6.9 million ounces of PGMs and 137 million pounds of cobalt in the measured and indicated mineral resource categories, Nickel Shäw is one of the largest undeveloped nickel projects in North America not controlled by a major mining company.

The PFS contemplates that the Nickel Shäw open pit would be mined using conventional open pit methods, with a LOM of over 19 years. From the open pit the ore would be trucked to a primary crusher located adjacent to the pit and conveyed out of the valley to a concentrator designed to process 45,000 tonnes per day ("tpd") of ore. The ore would be fed into a conventional Ni-Cu-PGM flotation concentrator designed to produce a bulk Ni-Cu-PGM concentrate "Bulk conc" or alternatively into split concentrates. The split concentrates would be a Ni concentrate "Ni conc" and a Cu concentrate "Cu conc", as economics dictate. Average annual LOM concentrates production ("dmt") is expected to be 103,100 dmt of Bulk conc, 95,000 dmt of Ni conc and 19,600 of dmt Cu conc. Total LOM payable metal production includes the following:

  • 614.3M lbs nickel;
  • 281.5M lbs copper;
  • 21.5 M lbs cobalt;
  • 626,500 troy ounces platinum;
  • 743,400 troy ounces palladium; and
  • 174,400 troy ounces gold.

The tailings would be stored in a tailings storage facility adjacent to the concentrator. Concentrate would be transported by truck 480 km to the Port of Skagway Ore Terminal. Power will be primarily sourced from a liquified natural gas ("LNG") power plant.

Social & Environmental

The Nickel Shäw Project lies within the Kluane First Nation ("KFN") core area as defined under the Umbrella Final Agreement between the Government of Canada , Government of Yukon and the Council of Yukon First Nations. Effective August 1, 2012 , an Exploration Cooperation Agreement was signed between the KFN and the Company. The KFN and the government of the Yukon Territory have provided very good support for the Nickel Shäw Project.

Ultramafic rocks from the project (in the form of tailings and waste rock) are being assessed for their ability to capture and store carbon. Test work conducted in 2022 confirmed the presence of brucite (a magnesium-rich mineral known to react quickly with CO2 in air) in a subset of samples. On a mass basis, from the achieved reactivity in the testwork, this may enable maximum sequestration of 2.1 kt CO2 per Mt tailings. The Company is evaluating further work which will include the creation of a mineralogy model based on the project's geochemical database to assess the spatial distribution of rocks within the Wellgreen deposit that have high potential to sequester carbon (see news release dated December 15, 2022 for additional details).

Summary of PFS Results

Pre-Tax NPV (5%), IRR

$547 million, 7.7%

After-Tax NPV (5%), IRR

$143 million, 5.8%

Undiscounted After-Tax Cash Flow (LOM)

$1.65 billion

After-Tax Payback Period

12.7 years

Life of Mine (LOM)

19.1 years

Capital Cost

- Initial

- Sustaining

- Total LOM

$1.7 billion

$0.6 billion

$2.3 billion

Operating Cost

$30.22 /mt milled

Mill Throughput

45,000 tpd

Initial 5 Year Annual Average Metal

- Nickel

- Copper

- Cobalt

- Platinum

- Palladium

- Gold

29.1 M lbs

9.1 M lbs

1.1 M lbs

27,400 troy oz

36,200 troy oz

7,700 troy oz

Life of Mine Strip Ratio (W:O)


Based on the assumed commodity prices noted above, the LOM revenue by metal is as follows: nickel – 62%; palladium – 14%; copper – 10%; platinum 6%; cobalt – 5% and gold – 3%.

NPV Sensitivities

The discount rate sensitivity is as follows:

Discount Rate

After-tax NPV

0 %

$1.7 billion

5% - base case

$143 million

10 %

($459) million

Sensitivity to Nickel and Copper Prices

The after-tax NPV ($Million's) at a 5% discount rate:

Nickel Price (US$)

Copper (US$)








$              3.00








$              3.25








$              3.50








$              3.75








$              4.00








$              4.25








$              4.50








Sensitivity to Energy Power Costs

The pre-tax and after-tax NPV ($Million's) at a 5% discount rate:

Power Cost ($kWhr)









Pre-tax NPV








After-tax NPV








Pre-tax IRR

10.4 %

9.9 %

9.4 %

8.9 %

8.4 %

7.7 %

7.3 %

After-tax IRR

8.2 %

7.7 %

7.3 %

6.8 %

6.4 %

5.8 %

5.5 %

Investment Tax Credit for Clean Technology Manufacturing

The Canadian 2023 federal budget proposed the introduction of a 30% refundable investment tax credit for investments in eligible property associated with eligible activities for clean technology manufacturing and processing, as well as critical mineral extraction and processing (the "Clean ITC"). The Clean ITC would apply to investments in certain depreciable property that is used all or substantially all for eligible activities. This would generally include machinery and equipment, including certain industrial vehicles and related control systems used in manufacturing, processing or critical mineral extraction. A portion of the Clean ITC would be recovered if eligible property is subject to a change in use or sold within a certain period of time.

As of this date, there are no specific details regarding the proposed Clean ITC and has not been legislated. Based on assumptions on the capital that could be eligible for the ITC, if the Company was able to utilize the 30% Clean ITC, the Company estimates that the after-tax NPV for the Project at a 5% discount rate would improve from $143 million to $336 million and the after-tax IRR would improve from 5.8% to 7.2%.


The initial capital expenditure contemplated in the PFS, to be incurred over the three-year pre-production period of the Project, amounts to approximately $1.7 billion , with the sustaining capital over the remainder of LOM amounts to approximately $0.6 billion . The LOM capital expenditure is summarized as follows:

Capital ($Million's)



Total LOM

Open Pit




























Operating Costs

The LOM operating costs are summarized as follows:

$/mt Milled









Concentrate Trucking


Carbon Tax




Future Opportunities and Value Enhancements

The PFS also identified a number of potential optimizations to the Project. These include:

  • Working with energy providers and Yukon government and other stakeholders on an energy strategy to reduce the costs for the project;
  • Additional metallurgical testwork to improve overall recoveries of all payable metals where a 1% recovery improvement represents approximately an after-tax $111 M improvement to the NPV at a 5% discount rate; and
  • Continue drilling on the Arch target to define the potential resource which could provide the opportunity for an early project higher grade feed that may improve overall financial results.

Nickel Creek Platinum Corp. (TSX: NCP; OTCQB: NCPCF) is a Canadian mining exploration and development company advancing its 100%-owned Nickel Shäw Project ("Project"). The Project has exceptional access to infrastructure, located three hours west of Whitehorse via the paved Alaska Highway, which further offers year-round access to deep-sea shipping ports in southern Alaska.

The Company is led by a management team with a proven track record of successful discovery, development, financing and operation of large-scale projects. Our vision is to create value for our shareholders by becoming a leading North American nickel, copper, cobalt and PGM producer.

Qualified Persons

The PFS was overseen by AGP and the technical information disclosed in this news release was reviewed and approved by Gordon Zurowski of AGP. Mr. Zurowski is a "qualified person" as defined in NI 43-101 - Standards of Disclosure for Mineral Projects ("NI 43-101") and an independent consultant to the Company. The scientific and technical information disclosed in this news release in relation to metallurgical testing, including with respect to 2022-23 variability testwork, was reviewed and approved by Gordon Marrs , P. Eng., of XPS who is a "qualified person" as defined in NI 43-101 and an independent consultant to the Company.

All other scientific and technical information disclosed in this news release was reviewed and approved by Cameron Bell , Nickel Creek's Geological Consultant and a "qualified person" as defined in NI 43-101. Please see the technical report ( September 2018 ) filed under the Company's profile at , for a description of the Company's data verification and QA/QC procedures.

Cautionary Note Regarding Forward-Looking Information

This news release includes certain information that may be deemed "forward-looking information". Forward-looking information can generally be identified by the use of forward-looking terminology such as "may", "will", "expect", "intend", "believe", "continue", "plans" or similar terminology, or negative connotations thereof. All information in this release, other than information of historical facts, including, without limitation, regarding the results of  technical test work, the estimated mineral resource, the prospect of any future potential economic viability of the Project, future commodity prices and the potential for them to improve, that a feasibility study will ever be commenced and completed, the potential to identify additional mineralization beyond the known resource, timing of  further work on the Project, future demand for nickel and copper concentrates, future demand for battery products, statements concerning the availability and impact of the Clean ITC, the ability of the Company to identify additional opportunities to create shareholder value, and general future plans and objectives for the Company and the Project, are forward-looking information that involve various risks and uncertainties. Although the Company believes that the expectations expressed in such forward-looking information are based on reasonable assumptions, such expectations are not guarantees of future performance and actual results or developments may differ materially from those in the forward-looking information.

This news release also contains references to estimates of mineral resources. The estimation of mineral resources is inherently uncertain and involves subjective judgments about many relevant factors. Mineral resources that are not mineral reserves do not have demonstrated economic viability. The accuracy of any such estimates is a function of the quantity and quality of available data, and of the assumptions made and judgments used in engineering and geological interpretation, which may prove to be unreliable and depend, to a certain extent, upon the analysis of drilling results and statistical inferences that may ultimately prove to be inaccurate. Mineral resource estimates may have to be re-estimated based on, among other things: (i) fluctuations in nickel, copper or other mineral prices; (ii) results of drilling; (iii) results of metallurgical testing and other studies; (iv) changes to proposed mining operations, including dilution; (v) the evaluation of mine plans subsequent to the date of any estimates; and (vi) the possible failure to receive or maintain required permits, approvals and licences.

For more information on the Company and the key assumptions, risks and challenges with respect to the forward-looking information discussed herein, and about our business in general, investors should review the Company's most recently filed annual information form, and other continuous disclosure filings which are available at . Readers are cautioned not to place undue reliance on forward-looking information. The Company does not undertake to update any forward-looking information, except in accordance with applicable securities laws.

Cision View original content to download multimedia:

SOURCE Nickel Creek Platinum Corp.

Cision View original content to download multimedia:

News Provided by Canada Newswire via QuoteMedia

Keep reading...Show less
Mount Burgess Mining NL

Kihabe-Nxuu Polymetallic Project Silver/Gallium Potential

In response to recent enquiries, Mount Burgess Mining Ltd (MTB:ASX, the “Company”) is pleased to update the silver potential of the Kihabe-Nxuu Project (“Project”) in Botswana. With the recent increase in silver prices and multiple forecasts predicting a structural deficit over the coming years, the importance of the silver content of the Project has increased substantially.

Keep reading...Show less

Registration Opens for the Inaugural Mining, Metals and the Circular Economy Conference

Early bird delegate passes are now on sale for the inaugural Mining, Metals and the Circular Economy conference, scheduled to take place at the ICC Sydney on 29 & 30 October 2024.

The launch of this event is timely, as circularity in the mining and metals industry is important for reaching net-zero goals and global decarbonisation, while also addressing the rising demand for minerals required for future technologies and other vital materials.

Organised by Beacon Events, the Mining, Metals and the Circular Economy conference will be co-located with the International Mining and Resources Conference (IMARC), providing attendees with unprecedented access to industry experts and thought leaders in the mining sector, fostering a dynamic exchange of innovative ideas and best practices. What sets this conference apart is that it is the world’s first and only event to explore the global context of process and product circularity throughout the mining industry’s value chain.

Keep reading...Show less
Aldoro Resources

Latest Kameelburg Assays Up To 10.38% Nb2o5 and 9.89% TREO

Aldoro Resources Ltd (“Aldoro”, “The Company”) (ASX: ARN) is pleased to provide an update on the large-scale geological mapping campaign at the Kameelburg Carbonatite Project, targeting priority areas across the southern and eastern margins of the large carbonatite plug.

Keep reading...Show less
Firetail Resources

Firetail Resources

Keep reading...Show less
Aura Energy

Aura Increases Tiris’ Mineral Resources by 55% to 91.3 Mlbs U3O8

Resource growth adds confidence in future expansion and scale opportunities

Aura Energy Limited (ASX: AEE, AIM: AURA) (“Aura” or “the Company”) is pleased to provide an update on the Mineral Resource Estimate (“MRE”) for the Tiris Uranium Project (“Tiris” or the “Project”) in Mauritania.

Keep reading...Show less
  Rimfire Pacific Mining Limited

Latest Assays Demonstrate Significant Increase in Murga Scandium Grades

Rimfire Pacific Mining (ASX: RIM, “Rimfire” or “the Company”) is pleased to advise that re-assaying of aircore drill samples from the Murga Scandium Prospect has demonstrated a significant increase in scandium grade for the prospect, which is located on Rimfire’s Fifield Project 70kms NW of Parkes NSW (Figure 1).

Keep reading...Show less

Latest Press Releases

Related News