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    Alpine Immune Sciences Shares New Preclinical Data

    Bryan Mc Govern
    Dec. 06, 2017 09:19AM PST
    Biotech Investing

    Alpine Immune Sciences announced it released the results of a preclinical study of immuno-oncology molecules derived from the company’s variant immunoglobulin (Ig) domain (vIgD) platform.

    Alpine Immune Sciences (NASDAQ:ALPN) announced it released the results of a preclinical study of immuno-oncology molecules derived from the company’s variant immunoglobulin (Ig) domain (vIgD) platform.
    As quoted in the press release:

    Alpine scientists fused these novel molecules with trastuzumab with the goal of activating T cells against HER2-positive tumors in the tumor microenvironment. Results showed these trastuzumab-ICOSL “V-mAbs” promoted T cell proliferation and cytokine secretion and enhanced killing of tumor cells. The data were presented in a poster session, titled “Treatment: Novel Targets and Targeted Agents (abstract # P1-09-10),” during the 40th Annual San Antonio Breast Cancer Symposium (SABCS).
    “These preclinical data clearly indicate that the V-mAb format for our unique vIgD platform can yield novel HER2-targeted, T cell-activating immunotherapies,” said Stanford Peng, M.D., Ph.D., Executive Vice President of Research and Development and Chief Medical Officer of Alpine. “With these findings, we are encouraged that the V-mAb format more broadly will be able to enable target- or tumor-specific immune modulation by our vIgDs for this and many other therapeutic applications.”

    Click here to read the full press release.

    Source: www.businesswire.com

    breast cancerpreclinical datat cellschief medical officer
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